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Two issues regarding the human rhinoviruses: the inhibitory effect of 2A protease on the induction of interferon and a search for a natural animal host

Grant number: 12/03700-0
Support Opportunities:Scholarships in Brazil - Post-Doctoral
Effective date (Start): July 01, 2012
Effective date (End): June 30, 2016
Field of knowledge:Biological Sciences - Microbiology - Biology and Physiology of Microorganisms
Principal Investigator:Eurico de Arruda Neto
Grantee:Talita Bianca Gagliardi
Host Institution: Faculdade de Medicina de Ribeirão Preto (FMRP). Universidade de São Paulo (USP). Ribeirão Preto , SP, Brazil
Associated scholarship(s):12/17601-4 - Study of the inhibitory effect of the protease 2A of different human rhinoviruses on induction of interferon, BE.EP.PD


Human rhinoviruses (HRV) are the most frequent agent of respiratory infections in humans. There are 150 HRV-types that can co-circulate and co-infect the same person, as was shown in some clinical studies. The co-infection is the first step to occur the genetic recombination and to result new chimera progenies. The detection of recombinant genomes of HRV has been done by Bioinformatic. A previously study in our lab shown the formation of recombinant HRV genomes with a high and variable frequency, in order to specie and group (major/minor) of HRV. It is necessary to investigate the mechanism of genome recombination in HRV that could explain those differences. So we will do in this project experiments in vitro using two diferent HRV co-infecting HeLa cells, considering different times of inoculation for each virus.The first response to the natural viral infection is by interferon (IFN), whose activation inhibits the replication of the most of viruses. By the way, it was shown to poliovirus (PV) that the viral protease 2A has an antiviral effect in the IFN response. A colaboration with the Prof. Dr. Vincent Racaniello, who participated in those studies about IFN and PV, will permit us to investigate the mechanism IFN - 2APRO for HRV during a pos-doc sandwich on his lab at the Columbia University (USA). Another important aspect, not very studied yet, about HRV is the possibility to exist a wild non-human host, like has one for influenza. Because now we have acess to samples from wild animals of different species, and wild birds and another ones from Zoo (São Paulo city), we have the chance to test them to picornaviruses by PCR in order to looking for a wild host for HRV.

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Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
SABINO-SANTOS, JR., GILBERTO; MOTTA MAIA, FELIPE GONCALVES; MARTINS, RONALDO BRAGANCA; GAGLIARDI, TALITA BIANCA; DE SOUZA, WILLIAM MARCIEL; MUYLAERT, RENATA LARA; DE SOUZA LUNA, LUCIANO KLEBER; MELO, DANILO MACHADO; CARDOSO, RICARDO DE SOUZA; BARBOSA, NATALIA DA SILVA; et al. Natural infection of Neotropical bats with hantavirus in Brazil. SCIENTIFIC REPORTS, v. 8, . (12/03700-0, 12/04096-0, 16/02568-2, 12/24150-9, 15/05354-0, 13/06380-0, 11/19897-5, 11/06810-9, 14/02438-6, 11/22663-6, 15/06142-7)

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