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Evaluation of individual variability observed in mice behavioral alterations after chronic administration of nicotine

Grant number: 12/05531-1
Support type:Scholarships in Brazil - Scientific Initiation
Effective date (Start): June 01, 2012
Effective date (End): December 31, 2013
Field of knowledge:Biological Sciences - Pharmacology - Neuropsychopharmacology
Principal researcher:Maria Gabriela Menezes de Oliveira
Grantee:Liz Paola Domingues
Home Institution: Escola Paulista de Medicina (EPM). Universidade Federal de São Paulo (UNIFESP). Campus São Paulo. São Paulo , SP, Brazil


Tobacco consumption has originated in ancient America, spreading through Europe from 16th century and having lots of ways of consumption throughout the centuries, until the rising of cigarette in the middle of 19th century. Currently, around a third of world's population is smoker and more than five million of these people are led to death, by year, due to this habit. Nicotine is the active principle of tobacco and, as well as other potentially addictive substances, is able to change the organization of the central nervous system, favoring the installation of dependence condition. Some of the neuroadaptation developed with the chronic use of nicotine are related with the process of tolerance to its depressant effects and subsequent behavioral sensitization, which is common to all psychoactive substances and is characterized by gradual and longstanding increase in locomotor activity induced by repeated administration of drugs of abuse. Despite being well established procedures, as the tolerance to the depressant effects as the behavioral sensitization can either manifest or not, once there is a significant individual variability in this expression. Several factors are related with this individual variability, between psychological, biological and environmental. This project seeks to understand the factors who leads to behavioral sensitization and its relationship with the individual variability observed in this process. (AU)

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Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
DOMINGUES, LIZ PAOLA; ANTONIO, BRUNO DE BRITO; MENEZES DE OLIVEIRA, MARIA GABRIELA; HARTMANN DE QUADROS, ISABEL MARIAN. Consequence of Two Protocols of Social Defeat Stress on Nicotine-Induced Psychomotor Effects in Mice. BIOMED RESEARCH INTERNATIONAL, . (12/05531-1)

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