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Surface chemistry manipulation of silver-based nanocomposites: study of biocidal effect against enveloped virus

Grant number: 12/05481-4
Support type:Scholarships in Brazil - Post-Doctorate
Effective date (Start): June 01, 2012
Effective date (End): April 27, 2015
Field of knowledge:Physical Sciences and Mathematics - Chemistry - Physical-Chemistry
Principal researcher:Mateus Borba Cardoso
Grantee:Juliana Martins de Souza e Silva
Home Institution: Centro Nacional de Pesquisa em Energia e Materiais (CNPEM). Ministério da Ciência, Tecnologia e Inovações (Brasil). Campinas , SP, Brazil
Associated scholarship(s):13/12190-9 - Understanding the activity of functionalized nanoparticles against virus using coherent diffraction imaging, BE.EP.PD


The project here described aims the synthesis of silver nanoparticles (AgNPs) covered by a shell of mesoporous silica (SM) functionalized with mercapto, glycidyl, isocyanate, amino or phenyl ethyl. Considering that AgNPs are effective antimicrobial agents, the objective of this study is obtaining a system with virucidal activity. The modification of the surface chemistry of AgNPs-SM with the above mentioned functional groups aims at finding a system in which the strong interaction with the virus enables the therapeutic effect of the system under study. During the synthesis process, structures obtained will be characterized by UV-Vis spectroscopy, small angle X-ray scattering (SAXS), transmission electron microscopy (TEM) and X-ray diffraction (XRD). For determining size and organization of pores in SM, N2 adsorption/desorption curves will be obtained. The degree of nanoparticles functionalization will be determined by Fourier transform infrared spectroscopy (FTIR) and by zeta potential analysis. AgNPs-SM antimicrobial activity will be studied and the presence of each functional group will be correlated to the virucidal efficiency of the system against baculovirus and, in a second stage, against lentivirus. Evaluation of the AgNPs-SM cytotoxicity against mammalian cells will take place in parallel to the above described research to make possible their use in biological systems.

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Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
DE SOUZA E SILVA, JULIANA MARTINS; MELO HANCHUK, TALITA DINIZ; SANTOS, MURILO IZIDORO; KOBARG, JOERG; BAJGELMAN, MARCIO CHAIM; CARDOSO, MATEUS BORBA. Viral Inhibition Mechanism Mediated by Surface-Modified Silica Nanoparticles. ACS APPLIED MATERIALS & INTERFACES, v. 8, n. 26, p. 16564-16572, . (13/12190-9, 12/05481-4, 14/22322-2)

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