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Role of NOD2 receptor on osteoclastogenesis

Grant number: 12/05319-2
Support Opportunities:Scholarships in Brazil - Scientific Initiation
Effective date (Start): June 01, 2012
Effective date (End): May 31, 2013
Field of knowledge:Biological Sciences - Pharmacology - Biochemical and Molecular Pharmacology
Principal Investigator:Sandra Yasuyo Fukada Alves
Grantee:Marcela Ribeiro da Cunha Fernandes Holanda
Host Institution: Faculdade de Ciências Farmacêuticas de Ribeirão Preto (FCFRP). Universidade de São Paulo (USP). Ribeirão Preto , SP, Brazil


The bacterial plaque has been identified as an etiological agent in the pathogenesis of the periodontal disease (PD). The NOD-like receptors (NLRs) are cytoplasmic proteins that sense microbial byproducts released by invasive bacteria. There is no data in the literature describing the role of NLRs in osteoclastogenesis. Since periodontopathogenic bacteria are able to invade and colonize some periodontal tissue cells, we hypothesize that NLRs activation by bacterial products may play an important role in the cornification of the inflammatory process and aggravation of bone loss on advanced periodontitis. The purpose of this study is to determine the role of NOD2 receptors activation, by Porphyromonas gingivalis, on immune response stimulation and osteoclastogenesis in vitro. For this, we will perform osteoblasts culture and evaluate the mediators released after NOD2 receptor activation. We will also evaluate the role NOD2 receptors activation on osteoclasts differentiation. The findings of the present study will give rise to a better understanding of the mechanisms underlying osteoclastogenesis and bone resorption, as well as provide knowledge that can help the development of new therapeutic targets for PD treatment.(AU)

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