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Effects of physical exercise associated with creatine supplementation on bone mass in ovariectomized rats

Grant number: 12/04695-0
Support Opportunities:Scholarships in Brazil - Master
Effective date (Start): May 01, 2012
Effective date (End): April 30, 2014
Field of knowledge:Health Sciences - Physical Education
Principal Investigator:Bruno Gualano
Grantee:Igor Hisashi Murai
Host Institution: Escola de Educação Física e Esporte (EEFE). Universidade de São Paulo (USP). São Paulo , SP, Brazil


The aim of this project will be to investigate the preventive effects of creatine supplementation associated or not with exercise on bone mass in ovariectomized rats, experimental model of postmenopausal osteoporosis. Sixty female rats (12 weeks old), will be evaluated by a randomized placebo-controlled study, divided into five groups (n=12 per group): i. sham-operated (SHAM); ii. ovariectomized (OVX), sedentary and treated with placebo (OVX-Pl); iii. OVX, sedentary and treated with creatine (OVX-Cr); iv. OVX, trained and treated with placebo (OVX-Tr-Pl) and v. OVX, trained and treated with creatine (OVX-Tr-Cr). Will be evaluated the bone mineral density, histomorphometric analysis, serum markers of bone resorption and formation and biomechanical properties of bone tissue.

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Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
MURAI, I. H.; ROSCHEL, H.; PABIS, L. V. S.; TAKAYAMA, L.; DE OLIVEIRA, R. B.; DOS SANTOS PEREIRA, R. T.; DANTAS, W. S.; PEREIRA, R. M. R.; JORGETTI, V.; BALLESTER, R. Y.; et al. Exercise training, creatine supplementation, and bone health in ovariectomized rats. OSTEOPOROSIS INTERNATIONAL, v. 26, n. 4, p. 1395-1404, . (12/04695-0)
Academic Publications
(References retrieved automatically from State of São Paulo Research Institutions)
MURAI, Igor Hisashi. Effects of exercise training associated with creatine supplementation on bone mass of ovariectomized rats. 2014. Master's Dissertation - Universidade de São Paulo (USP). Escola de Educação Física e Esportes (EEFE/BT) São Paulo.

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