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Development and evaluation of micro and nanotechnology systems containing green coffee oil additive with alpha tocopherol.

Grant number: 12/04071-7
Support Opportunities:Scholarships in Brazil - Doctorate
Effective date (Start): June 01, 2012
Effective date (End): March 31, 2015
Field of knowledge:Health Sciences - Pharmacy - Pharmaceutical Technology
Principal Investigator:Luis Alexandre Pedro de Freitas
Grantee:Anna Beatriz Frejuello Limoli Nosari
Host Institution: Faculdade de Ciências Farmacêuticas de Ribeirão Preto (FCFRP). Universidade de São Paulo (USP). Ribeirão Preto , SP, Brazil


Technology has an important role in determining of the industry competitiveness. The technological innovation allows the development of new products and processes and the production of supplies with a maximum recovery, reducing costs. Among the various sectors that adopt technology strategies for the development of new products stands out the Cosmetics Industry, this is an area in frank expansion. The use of the technology allows the formulation of cosmetic products more stable and effective and makes possible the production of new delivery systems. Micro and nanostructured systems are examples of a global technological trend that has been widely used in cosmetic formulations such as sunscreen, anti-aging, products for the prevention of cellulite, localized fat, among others. Among the numerous compounds used in cosmetics stands out the green coffee oil, a product rich in fatty acids, sterols, di-and triterpenes, which gives the skin a number of actions, such as moisturizing, regenerative and stimulating addition to exert antioxidant action. The present work aims to develop micro and nano systems for application in the field of cosmetics containing green coffee oil and ±-tocopherol, as well as study and evaluate its stability, the antioxidant potential, the sun protection factor and permeation and retention skin of the systems developed by comparing the results with a conventional formulation.

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Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
NOSARI, ANNA B. F. L.; LIMA, JULIANA F.; SERRA, OSVALDO A.; FREITAS, LUIS ALEXANDRE P.. Improved green coffee oil antioxidant activity for cosmetical purpose by spray drying microencapsulation. REVISTA BRASILEIRA DE FARMACOGNOSIA-BRAZILIAN JOURNAL OF PHARMACOGNOSY, v. 25, n. 3, p. 307-311, . (11/20872-7, 12/04071-7)
Academic Publications
(References retrieved automatically from State of São Paulo Research Institutions)
NOSARI, Anna Beatriz Frejuello Limoli. Development and evaluation of micro and nanoparticles containing green coffee oil for dermocosmetic applications. 2015. Doctoral Thesis - Universidade de São Paulo (USP). Faculdade de Ciências Farmacêuticas de Ribeirão Preto (PCARP/BC) Ribeirão Preto.

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Filed patent(s) as a result of this research project

MICROPARTÍCULAS E NANOPARTÍCULAS LIPÍDICAS SÓLIDAS BR1020120014483 - Universidade de São Paulo (USP) . Luis Alexandre Pedro de Freitas ; Anna Beatriz Frejuello Limoli Nosari - January 2012, 23