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Pharmacokinetic evaluation of the crude extract and secondary metabolites from the leaves of Copaifera langsdorffii Desf.

Grant number: 12/03852-5
Support Opportunities:Scholarships in Brazil - Doctorate
Effective date (Start): June 01, 2012
Effective date (End): March 12, 2016
Field of knowledge:Health Sciences - Pharmacy - Pharmacognosy
Principal Investigator:Jairo Kenupp Bastos
Grantee:Juliana de Carvalho da Costa
Host Institution: Faculdade de Ciências Farmacêuticas de Ribeirão Preto (FCFRP). Universidade de São Paulo (USP). Ribeirão Preto , SP, Brazil
Associated scholarship(s):13/09666-1 - Pharmacokinetic evaluation of secondary metabolites from the leaves of Copaifera langsdorffii Desf, BE.EP.DR


Plants of the genus Copaifera L., popularly known as "copaibeiras" or "pau d'óleo", are native of tropical regions of Latin America and West Africa. The oil-resin obtained through a small incision in the trunk of the tree is a valuable medicine in folk medicine and was recently included as one of the first monographs of Herbal Medicines Form in the Brazilian Pharmacopeia. However, in relation to the aerial parts of the genus Copaifera, there are few studies reporting its chemical composition and biological activities. Moreover, in recent years, our research group has been studying the oil-resin and aerial parts of the Copaifera langsdorffii Desf. and it was observed that the hydroalcoholic extract of leaves showed antilithiatic activity in vivo. Aiming to discover the possible active compounds related to this activity, we isolated and identified some compounds of this plant. Quercetin-3-O-±-L-rhamnopyranoside (quercitrin), 4-methoxy-3-O-galloylquinic acid and C. langsdorffii leaves extract will be studied in the present work, pharmacokinetically, in rats treated with single doses of these compounds. Whereas active compounds should be eliminated renally in order to show antilithiatic activity, it will be investigated the pharmacokinetic behavior of these components in plasma and urine, as well as the identification of possible metabolites by high performance liquid chromatography in tandem (HPLC-MS/MS). The pharmacokinetic parameters will be calculated by WinNonlin software.Keywords: Copaifera langsdorffii, quercitrin, galloylquinic acid, pharmacokinetic, HPLC-MS/MS.

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Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
DA COSTA, JULIANA DE CARVALHO; MOTTA, ERICK V. S.; BARRETO, FABIANO; DE ARAUJO, BIBIANA VERLINDO; DERENDORF, HARTMUT; BASTOS, JAIRO KENUPP. Development and Validation of a Sensitive UFLC-MS/MS Method for Quantification of Quercitrin in Plasma: Application to a Tissue Distribution Study. ACS OMEGA, v. 4, n. 2, p. 3527-3533, . (13/09666-1, 11/13630-7, 12/03852-5)
DA SILVA MOTTA, ERICK VICENTE; DA COSTA, JULIANA DE CARVALHO; BASTOS, JAIRO KENUPP. A validated HPLC-UV method for the analysis of galloylquinic acid derivatives and flavonoids in Copaifera langsdorffii leaves. JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES, v. 1061, p. 240-247, . (12/03852-5, 11/13630-7, 12/01336-0)
Academic Publications
(References retrieved automatically from State of São Paulo Research Institutions)
COSTA, Juliana de Carvalho da. Pharmacokinetic evaluation of the crude extract and secondary metabolites from the leaves of Copaifera langsdorffii Desf. 2016. Doctoral Thesis - Universidade de São Paulo (USP). Faculdade de Ciências Farmacêuticas de Ribeirão Preto (PCARP/BC) Ribeirão Preto.

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