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Effects of aerobic physical training on inflammatory and apoptotic process in hypothalamic neurons of hungry control in high-fat diet-induced obese mice.

Grant number: 12/01750-0
Support Opportunities:Scholarships in Brazil - Doctorate
Effective date (Start): August 01, 2012
Effective date (End): July 31, 2015
Field of knowledge:Health Sciences - Physical Education
Principal Investigator:José Rodrigo Pauli
Grantee:Rodolfo Marinho
Host Institution: Faculdade de Ciências Aplicadas (FCA). Universidade Estadual de Campinas (UNICAMP). Limeira , SP, Brazil


In experimental models, hypothalamic inflammation is an early and determining factor in the installation and progression of obesity. Pharmacological and gene-based approaches have proven efficient in restraining inflammation and correcting the obese phenotypes. However, the role of aerobic physical training in the modulation of hypothalamic inflammation is little-known. The consumption of a high-fat diet activates the expression or the activity of inflammatory responsive proteins such as SOCS3, IKK, JNK, iNOS and TLR4 which impair leptin and insulin signaling in the hypothalamus, thus, disrupting the main satietogenic and adipostatic routes that maintain a stable body mass. In addition, new evidence showed that the high-fat diet activates hypothalamic IKK²/NF-ºB, at least in part, through elevated endoplasmic reticulum stress in the hypothalamus and that these phenomena are associated also with central insulin and leptin resistance, hyperphagia and body weight gain in animals. Instead, exercise has long been reported to reduce body weight and visceral adiposity, increasing the energy expenditure and improving glycaemic control in overweight or diabetes type 2 patients. Thus, the main aim of the present study is to verify the role of effect of physical training to prevent the inflammation and apoptosis in hypothalamic cells of obese mice fed with a high-fat diet

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Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
RODOLFO MARINHO; LEANDRO PEREIRA DE MOURA; BÁRBARA DE ALMEIDA RODRIGUES; LUCIANA SANTOS SOUZA PAULI; ADELINO SANCHEZ RAMOS DA SILVA; ELOIZE CRISTINA CHIARREOTTO ROPELLE; CLAUDIO TEODORO DE SOUZA; DENNYS ESPER CORRÊA CINTRA; EDUARDO ROCHETE ROPELLE; JOSÉ RODRIGO PAULI. Efeitos de diferentes intensidades de exercício físico sobre a sensibilidade à insulina e atividade da proteína quinase B/Akt no músculo esquelético de camundongos obesos. Einstein (São Paulo), v. 12, n. 1, p. 82-89, . (12/01750-0)
MARINHO, RODOLFO; MUNOZ, VITOR R.; PAULI, LUCIANA S. S.; ROPELLE, ELOIZE C. C.; DE MOURA, LEANDRO P.; MORAES, JULIANA C.; MOURA-ASSIS, ALEXANDRE; CINTRA, DENNYS E.; DA SILVA, ADELINO S. R.; ROPELLE, EDUARDO R.; et al. Endurance training prevents inflammation and apoptosis in hypothalamic neurons of obese mice. Journal of Cellular Physiology, v. 234, n. 1, p. 880-890, . (12/01750-0)
Academic Publications
(References retrieved automatically from State of São Paulo Research Institutions)
MARINHO, Rodolfo. Efeitos do treinamento físico aeróbio sobre o processo inflamatório e apoptótico em neurônios hipotalâmicos de controle da fome em camundongos obesos induzidos por dieta hiperlipídica. 2015. Doctoral Thesis - Universidade Estadual Paulista (Unesp). Instituto de Biociências. Rio Claro Rio Claro.

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