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Relationship between fat mass and bone: metabolic interaction between vitamin D, vitamin D receptor genotype, osteocalcin and leptin in adolescentes

Grant number: 11/22768-2
Support Opportunities:Scholarships in Brazil - Doctorate (Direct)
Effective date (Start): May 01, 2012
Effective date (End): August 31, 2015
Field of knowledge:Health Sciences - Nutrition - Nutrition Biochemistry
Principal Investigator:Lígia Araújo Martini
Grantee:Kelly Virecoulon Giudici
Host Institution: Faculdade de Saúde Pública (FSP). Universidade de São Paulo (USP). São Paulo , SP, Brazil
Associated scholarship(s):13/15823-2 - Associations between vitamin D, osteocalcin, adipokines and markers of energy metabolism among Brazilian and American adolescents, BE.EP.DD


Vitamin D - 1,25(OH)2D3 conducts its endocrine actions by genomic and non-genomic mechanisms. Several organs, including liver, pancreas, muscle, fat tissue and bone, express the gene for vitamin D receptor. Leptin - which is a hormone produced by fat tissue that has important effects on energy homeostasis and control of satiety - and osteocalcin genes both are controlled by vitamin D receptor endocrine actions. The effects of obesity on bone mass of adolescents are not fully understood. Studies have shown that bone density gain, typical of adolescence, may be greater in obese adolescents, however others suggest lower bone mass in these individuals, after adjusting for height. Adipokines such as leptin seem to have strong participation in the regulation of bone metabolism in this population. Objective: This study aims to investigate the relationship between 25 hydroxyvitamin D blood concentrations and single nucleotide polymorphisms in the vitamin D receptor gene with osteocalcin and leptin concentrations in adolescents, and to explore metabolic parameters related to overweight and obesity in adolescents. Methods: This cross-sectional study will be conducted with 400 individuals from 14 to 19 years. Demographic and socio-economic data will be assessed, as well as anthropometric measures and food intake. Body composition will be evaluated by DEXA (Dual Energy X-ray absorptiometry) and blood collection (12 hours fasting) to determine the presence of single nucleotide polymorphisms in the gene of the vitamin D receptor will be carried out PCR reactions (polymerase chain reaction). Bioelectrical impedance and blood collection (after 12 hour-fasting) will be held to biochemical analysis of 25 hydroxyvitamin D, parathyroid hormone, glucose, insulin, carboxylated and uncarboxylated osteocalcin, leptin, adiponectin, lipid profile and creatinine. PCR (Polymerase Chain Reaction) will be used to determine the presence of single nucleotide polymorphisms in the vitamin D receptor gene. (AU)

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Scientific publications (4)
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
LOPES, MARIANA P.; GIUDICI, KELLY V.; MARCHIONI, DIRCE M.; FISBERG, REGINA M.; MARTINI, LIGIA A.. Relationships between n-3 polyunsaturated fatty acid intake, serum 25 hydroxyvitamin D, food consumption, and nutritional status among adolescents. Nutrition Research, v. 35, n. 8, p. 681-688, . (11/22768-2, 12/21130-7, 12/11061-8)
GIUDICI, K. V.; FISBERG, R. M.; MARCHIONI, D. M.; MARTINI, L. A.. Comparisons of physical activity, adipokines, vitamin D status and dietary vitamin D intake among adolescents. JOURNAL OF HUMAN NUTRITION AND DIETETICS, v. 30, n. 3, p. 369-377, . (11/22768-2, 12/11061-8)
GIUDICI, KELLY VIRECOULON; MARTINI, LIGIA ARAUJO. Comparison between body mass index and a body shape index with adiponectin/leptin ratio and markers of glucose metabolism among. ANNALS OF HUMAN BIOLOGY, v. 44, n. 6, p. 489-494, . (11/22768-2, 12/11061-8)
GIUDICI, KELLY VIRECOULON; FISBERG, REGINA MARA; LOBO MARCHIONI, DIRCE MARIA; EMO PETERS, BARBARA SANTAROSA; MARTINI, LIGIA ARAUJO. Crosstalk Between Bone and Fat Tissue: Associations Between Vitamin D, Osteocalcin, Adipokines, and Markers of Glucose Metabolism Among Adolescents. JOURNAL OF THE AMERICAN COLLEGE OF NUTRITION, v. 36, n. 4, p. 273-280, . (11/22768-2, 12/11061-8)
Academic Publications
(References retrieved automatically from State of São Paulo Research Institutions)
GIUDICI, Kelly Virecoulon. Relationship between fat mass and bone: associations between vitamin D, osteocalcin, adipokines and glucose homeostasis among children and adolescents. 2015. Doctoral Thesis - Universidade de São Paulo (USP). Faculdade de Saúde Pública (FSP/CIR) São Paulo.

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