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Functional analysis of antigen cancer / testis in glioblastoma.

Grant number: 11/15118-1
Support Opportunities:Scholarships in Brazil - Master
Effective date (Start): May 01, 2012
Effective date (End): July 31, 2013
Field of knowledge:Health Sciences - Medicine
Principal Investigator:Karina Ramalho Bortoluci
Grantee:Thaís Priscila Biassi
Host Institution: Instituto de Ciências Ambientais, Químicas e Farmacêuticas (ICAQF). Universidade Federal de São Paulo (UNIFESP). Campus Diadema. Diadema , SP, Brazil

Abstract

Glioblastoma (GBM),IV astrocytoma (WHO), primary brain tumor is the most frequent malignant in adults. A tumor characterized by being highly resistant to therapy, and since the poor prognosis of patients with glioblastomas and current treatment, new therapeutic approaches are needed. One attractive approach is the use of specific tumor antigens as targets to stimulate the patient's immune system. A prerequisite for the success of these strategies is the existence of genes that are exclusively or preferentially expressed in malignant tissues compared with normal tissues. Cancer-testis antigens (CTA) are considered as potential candidates for development of vaccine, because they are expressed in various tumors and their expression in human tissues is nearly restricted to germ cells of the testis and trophoblast cells. Allied to the fact that many of the findings present in placentation and gametogenesis, such as migration, invasion, immune escape, resistance to apoptosis and induction of angiogenesis are the same ones that give their malignant potential tumors, it is very important to understand the cellular function of these CTAs in tumor cells. So from the functional analysis of four genes validated CTAs with high expression in glioblastomas, not expressed in normal brain tissue is intended to: examine different cultures of GBM cell lines the overexpression and silencing the four CTAs; check for correlation with the expression of these antigens in GBM cell lines and proliferation, apoptosis, invasion, migration and cell cycle changes.

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Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
RODRIGUES-JUNIOR, DORIVAL MENDES; BIASSI, THAIS PRISCILA; CARLIN, VIVIANE; BURI, MARCUS VINICIUS; TORRECILHAS, ANA CLAUDIA; BORTOLUCI, KARINA RAMALHO; VETTORE, ANDRE LUIZ. OIP5 Expression Sensitize Glioblastoma Cells to Lomustine Treatment. JOURNAL OF MOLECULAR NEUROSCIENCE, v. 66, n. 3, p. 383-389, . (11/15118-1, 10/20218-2, 12/01597-8, 12/14837-7)

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