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Evaluaion of bone loss, by morphometric analysis, in hypertensive rats with periodontitis

Grant number: 11/24113-3
Support Opportunities:Scholarships in Brazil - Scientific Initiation
Effective date (Start): May 01, 2012
Effective date (End): December 31, 2012
Field of knowledge:Health Sciences - Dentistry - Periodontology
Principal Investigator:Mario Taba Junior
Grantee:Paula Cristina dos Santos
Host Institution: Faculdade de Odontologia de Ribeirão Preto (FORP). Universidade de São Paulo (USP). Ribeirão Preto , SP, Brazil


Hypertension (HBP), a highly prevalent disorder in the world population, is an important risk factor for cardiovascular disease. The inflammation is involved in hypertension by the action of pro-inflammatory mediators associated with endothelial dysfunction and increased arterial stiffness. It is demonstrated an association between the severity of periodontal disease (PD) and hypertension and also a relationship between changes in calcium metabolism and decreased bone mineral density in hypertensive individuals. However, little is known about the influence of hypertension on PD and bone repair. The purpose of this study is to evaluate in spontaneously hypertensive rats (SHR) with the ligature-induced periodontal disease the effects of hypertension in periodontal disease and bone repair, by morphometric analysis of the alveolar bone level changes.(AU)

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