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Bromelain extraction from pineapple residues using ethanol precipitation and its application in polymeric hydrogel

Grant number: 11/23076-7
Support type:Scholarships in Brazil - Scientific Initiation
Effective date (Start): August 01, 2013
Effective date (End): June 30, 2015
Field of knowledge:Health Sciences - Pharmacy - Pharmaceutical Technology
Principal researcher:Priscila Gava Mazzola
Grantee:Janaína Artem Ataide
Home Institution: Faculdade de Ciências Médicas (FCM). Universidade Estadual de Campinas (UNICAMP). Campinas , SP, Brazil
Associated scholarship(s):14/26304-9 - Evaluation of skin permeation of bromelain using in vitro diffusion experiment, BE.EP.IC


Bromelain is a set of proteolytic enzymes found in various parts such as bark, stem, leaves, and fruit of pineapple (Ananas comosus), and other species of the family Bromeliaceae. Due to its fibrinolytic, anti-inflammatory, and healing properties, it is used in treating diseases related to blood clotting, angina, indigestion, and respiratory problems. The purification of molecules is the subject of many studies being conducted to obtain bromelain. Ethanol precipitation is used in the extraction of biomolecules, due to the economic character of this solvent and the facility of isolating the target molecule. The aim of this project is to extract bromelain from the pineapple waste (bark), using the method of ethanol precipitation. For this, the determination of the solubility curves will be previously defined, changing the concentration of ethanol from 10 to 90% (v/v). Bromelain will be extracted in the best-found concentration. Another objective of this project is to incorporate the extracted bromelain in hydrogel and study its stability.(AU)

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Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
ATAIDE, JANAINA ARTEM; DE CARVALHO, NATHALIA MENDES; REBELO, MARCIA DE ARAUJO; CHAUD, MARCO VINICIUS; GROTTO, DENISE; GERENUTTI, MARLI; RAI, MAHENDRA; MAZZOLA, PRISCILA GAVA; JOZALA, ANGELA FAUSTINO. Bacterial Nanocellulose Loaded with Bromelain: Assessment of Antimicrobial, Antioxidant and Physical-Chemical Properties. SCIENTIFIC REPORTS, v. 7, . (11/23076-7, 16/05930-4)
ATAIDE, JANAINA ARTEM; CEFALI, LETICIA CARAMORI; REBELO, MARCIA DE ARAUJO; SPIR, LIVIA GENOVEZ; TAMBOURGI, ELIAS BASILE; JOZALA, ANGELA FAUSTINO; CHAUD, MARCO VINICIUS; SILVEIRA, EDGAR; GU, XIAOCHEN; MAZZOLA, PRISCILA GAVA. Bromelain Loading and Release from a Hydrogel Formulated Using Alginate and Arabic Gum. Planta Medica, v. 83, n. 10, p. 870-876, . (14/26304-9, 11/23076-7)

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