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In vitro analysis of the biomineralization and cell proliferation on nanohydroxyapatite/vertically aligned carbon nanotube scaffolds

Grant number: 12/02159-4
Support Opportunities:Scholarships in Brazil - Scientific Initiation
Effective date (Start): April 01, 2012
Effective date (End): March 31, 2013
Field of knowledge:Engineering - Materials and Metallurgical Engineering - Nonmetallic Materials
Principal Investigator:Anderson de Oliveira Lobo
Grantee:Tayra Rodrigues Brazil
Host Institution: Instituto de Pesquisa e Desenvolvimento (IP&D). Universidade do Vale do Paraíba (UNIVAP). São José dos Campos , SP, Brazil
Associated research grant:11/17877-7 - Development of new polymeric scaffolds by electrospinning technique with incorporation of vertically aligned carbon nanotubes and nanohidroxyapatite for bone tissue regeneration, AP.JP


Nanostructured biomaterials are promising because of their likeness with natural nanostructures of the extracellular-matrix of all body tissues. In the class of nanostructured materials the vertically aligned multiwalled carbon nanotubes (VACNT) have great potential for biomedical applications. VACNT present the unique properties of high electrical conductivity, high chemical stability, high mechanical strength and easiness of functional groups incorporation. Template-induced hydroxyapatite (HA) has broad prospects in the applied fields of regenerative medicine and bone repair because of excellent bioactive properties. The following studies will performed for these main aims: (i) Production and characterization of VACNTs films grown using microwave chemical vapor deposition; (ii) Superficial modification of VACNT using oxygen plasma etching (VACNT-O2); (iii) Production of HA/VACNT-O2 nanocomposites (iv) HA/VACNT-O2 composites biomineralization in vitro. The goal of this work will be show that the HA/VACNT-O2 nanocomposites can accelerate in vitro and in vivo biomineralization process. These studies are indispensable for production of nanobiomateriais for bone tissue regeneration. (AU)

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Scientific publications (4)
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
NEVES, MARCELE FLORENCIO; SILVA, GISLENE RODRIGUES; BRAZIL, TAYRA RODRIGUES; MARCIANO, FERNANDA ROBERTA; PACHECO-SOARES, CRISTINA; LOBO, ANDERSON OLIVEIRA. Calcification in vitro of biomineralizated nanohydroxyapatite/superydrophilic vertically aligned multiwalled carbon nanotube scaffolds. MATERIALS RESEARCH-IBERO-AMERICAN JOURNAL OF MATERIALS, v. 16, n. 3, p. 614-618, . (11/20345-7, 12/02159-4, 11/17877-7)
NEVES, MARCELE FLORENCIO; BRAZIL, TAYRA RODRIGUES; SILVA SOARES, LUIS EDUARDO; CORAT, EVALDO JOSE; MARCIANO, FERNANDA ROBERTA; LOBO, ANDERSON OLIVEIRA. In vitro biomineralization of a novel hydroxyapatite/superhydrophilic multiwalled carbon nanotube nanocomposite using simulated body fluids. MATERIALS RESEARCH-IBERO-AMERICAN JOURNAL OF MATERIALS, v. 16, n. 3, p. 650-654, . (11/20345-7, 12/02159-4, 11/17877-7)
SIQUEIRA, IDALIA A. W. B.; CORAT, MARCUS ALEXANDRE F.; CAVALCANTI, BRUNO DAS NEVES; RIBEIRO NETO, WILSON ALVES; MARTIN, AIRTON ABRAHAO; SUMAN BRETAS, ROSARIO ELIDA; MARCIANO, FERNANDA ROBERTA; LOBO, ANDERSON OLIVEIRA. In Vitro and in Vivo Studies of Novel Poly(D,L-lactic acid), Superhydrophilic Carbon Nanotubes, and Nanohydroxyapatite Scaffolds for Bone Regeneration. ACS APPLIED MATERIALS & INTERFACES, v. 7, n. 18, p. 9385-9398, . (11/20345-7, 12/02159-4, 11/17877-7)
BRAZIL, TAYRA RODRIGUES; DAS NEVES, MARCELE FLORENCIO; REGIANI, INACIO; MARCIANO, FERNANDA ROBERTA; LOBO, ANDERSON OLIVEIRA. Proposed model for biomineralization of novel nanohydroxyapatite/vertically aligned multiwalled carbon nanotube scaffolds. MATERIALS RESEARCH-IBERO-AMERICAN JOURNAL OF MATERIALS, v. 16, n. 3, p. 661-667, . (11/20345-7, 12/02159-4, 11/17877-7)

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