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Bioactive compounds release study from potentially active dendrimer prodrugs and drugs in neglected diseases

Grant number: 12/50034-6
Support Opportunities:Scholarships in Brazil - Post-Doctorate
Effective date (Start): June 01, 2012
Effective date (End): May 31, 2015
Field of knowledge:Health Sciences - Pharmacy
Principal Investigator:Elizabeth Igne Ferreira
Grantee:Jeanine Giarolla Vargas
Host Institution: Faculdade de Ciências Farmacêuticas (FCF). Universidade de São Paulo (USP). São Paulo , SP, Brazil


Parasitic infectious diseases, considered neglected diseases, represent a major public health concern in many countries and regions. The available drugs in therapy are, generally, toxic and have low efficacy. Therefore, the discovery and design of new chemotherapeutic agents are urgently needed. In this context, prodrugs and targeted drugs dendrimers may be useful. However, the active compound must be released from the dendrimers and the cleavage prediction represents a challenge for the scientific community. Considering that, the objective of this work is the creation of the Sector for Drug/Bioactive compounds Release from dendrimer compounds, prodrugs and targeted drugs, potentially active in neglected diseases at the Laboratory of Design and Synthesis of Chemotherapeutics Potentially Active in Neglected Diseases - LAPEN -Faculty of Pharmaceutical Sciences, University of São Paulo. This is an essential research area for evaluating the hydrolysis of labile linkage of the dendrimer compounds using different pH, in human plasma and rat liver homogenate. The molecules are being synthesized and they are part of LAPEN projects, such as master, doctoral and post-doctoral projects. This área is innovative and very interesting, thus, this new sector will have a great importance in developing of the group's work. In addition, molecular dynamics simulations of the complexes between esterase and derivatives, to assist in understanding the practical results, will be performed. The purpose of those studies is to aid in the understanding of the practical results and to complete the research previously developed, using molecular modeling, whose results have been recently published. (AU)

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Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
GIAROLLA, JEANINE; FERREIRA, ELIZABETH IGNE. Drug Design for Neglected Disease in Brazil. MINI-REVIEWS IN MEDICINAL CHEMISTRY, v. 15, n. 3, p. 220-242, . (12/50034-6)
SANTOS, SORAYA DA SILVA; GIAROLLA, JEANINE; PASQUALOTO, KERLY F. M.; FERREIRA, ELIZABETH I.. In silico study to analyse the disassembly of quercetin-targeted dendrimers potentially leishmanicide. MOLECULAR SIMULATION, v. 41, n. 18, p. 1495-1508, . (12/50034-6)
GIAROLLA, JEANINE; MESQUITA PASQUALOTO, KERLY FERNANDA; FERREIRA, ELIZABETH I.. Design and exploratory data analysis of a second generation of dendrimer prodrugs potentially antichagasic and leishmanicide. MOLECULAR DIVERSITY, v. 17, n. 4, p. 711-720, . (12/50034-6)

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