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Grant number: 11/22112-0
Support Opportunities:Scholarships in Brazil - Doctorate
Effective date (Start): May 01, 2012
Effective date (End): April 30, 2015
Field of knowledge:Biological Sciences - Pharmacology - Ethnopharmacology
Principal Investigator:José Maurício Sforcin
Grantee:Karina Basso Santiago
Host Institution: Instituto de Biociências (IBB). Universidade Estadual Paulista (UNESP). Campus de Botucatu. Botucatu , SP, Brazil


Propolis is a resinous product made by bees from several parts of plants, showing plenty of biological and pharmacological properties, and with a great importance in food and in the pharmaceutical industry. Caries and periodontal disease are infectious diseases that reflect an imbalance in the oral microbiota, whose agents can be transmitted. Chlorhexidine has been used as an anticarie agent, but its use is controversial due to side effects. There has been a search for new products with antimicrobial activity and fewer side effects,and herein we aim to investigate not only propolis but also an antimicrobial agent (chlorhexidine), and the association propolis / chlorhexidine on S. mutans and on the action of monocytes against this bacterium. The effect of these variables will be assessed on S. mutans, determining the minimum inhibitory concentration, on monocytes, evaluating the production of pro- and anti-inflammatory cytokines, and on the antibacterial activity of these cells. The quality of the association of propolis / chlorhexidine will be evaluated regarding its stability and a possible contamination according to the shelf time, in order to develop a potential pharmaceutical product, demonstrating the practical implication of this research project.

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Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
SANTIAGO, KARINA BASSO; CONTI, BRUNO JOSE; CARDOSO, ELIZA DE OLIVEIRA; GOLIM, MARJORIE DE ASSIS; SFORCIN, JOSE MAURICIO. Immunomodulatory/anti-inflammatory effects of a propolis-containing mouthwash on human monocytes. PATHOGENS AND DISEASE, v. 74, n. 8, . (12/14614-8, 11/22112-0)
Academic Publications
(References retrieved automatically from State of São Paulo Research Institutions)
SANTIAGO, Karina Basso. Caracterização de um produto odontológico à base de própolis: ações antibacteriana e imunomoduladora. 2015. Doctoral Thesis - Universidade Estadual Paulista (Unesp). Instituto de Biociências. Botucatu Botucatu.

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