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HPV Diversity and Cancer Risk

Grant number: 12/01513-9
Support Opportunities:Scholarships in Brazil - Master
Effective date (Start): April 01, 2012
Effective date (End): March 31, 2014
Field of knowledge:Biological Sciences - Biochemistry - Biochemistry of Microorganisms
Principal Investigator:Laura Cristina Sichero Vettorazzo
Grantee:Julio Cesar Betiol
Host Institution: Instituto do Câncer do Estado de São Paulo Octavio Frias de Oliveira (ICESP). Coordenadoria de Serviços de Saúde (CSS). Secretaria da Saúde (São Paulo - Estado). São Paulo , SP, Brazil


HPV evolution is closely related to viral tropism and carcinogenic potential. HPVs from the alfa-papillomavírus genus infect the anogenital and anal mucosas, and some HPV types of this genus cause approximately all cases of cervical cancer and tumors from other anogenital and extragenital regions. These HPV types, classified as high oncogenic risk, belong to 5 different species: alfa-5, -6, -7, -9 e -11. Moreover, among each species, type-specific behavior of persistence and carcinogenesis is observed. In a more detailed taxonomic level, HPV-16 molecular variants evolved in a manner to obtain clear differences concerning viral DNA persistence and risk of developing high grade cervical lesions. Nevertheless, little is known about the natural history of molecular variants of HPV types other than HPVs-16 and -18.Thus, the aim of this project is to characterize HPV genome diversity among genital and head and neck tumor samples. More specifically we aim to: (1) Identify the prevalence of HPV types in a series of genital and head and neck tumor samples; (2) Identify molecular variants detected in the cases of infection by some HPV of the high risk species alfa-9 (HPV-16, -31, -35, -52 e -58), alfa-7 (HPV-18 e -45), and alfa-6 (HPV-56) in these samples; (3) Identify HPV types and variants associated with specific histological types; and (4) Verify if the prevalence of the diverse HPV types and variants changed throughout the last 4 decades (1970-2010). The information regarding HPV prevalence and type-specific distribution is highly desired in order to evaluate the impact of HPV type-specific prophylactic vaccines.

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Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
J. BETIOL; L.L. VILLA; L. SICHERO. Impact of HPV infection on the development of head and neck cancer. Brazilian Journal of Medical and Biological Research, v. 46, n. 3, p. 217-226, . (12/01513-9, 11/09616-9)
BETIOL, JULIO C.; SICHERO, LAURA; DE OLIVAL COSTA, HENRIQUE O.; DE MATOS, LEANDRO L.; ANDREOLI, MARIA A.; FERREIRA, SILVANEIDE; FARAJ, SHEILA F.; DE MELLO, EVANDRO S.; SOBRINHO, JOAO S.; BRANDAO, LENINE G.; et al. Prevalence of human papillomavirus types and variants and p16(INK4a) expression in head and neck squamous cells carcinomas in Sao Paulo, Brazil. INFECTIOUS AGENTS AND CANCER, v. 11, . (12/01513-9, 08/57889-1, 11/09616-9)
Academic Publications
(References retrieved automatically from State of São Paulo Research Institutions)
BETIOL, Julio Cesar. HPV prevalence in head and neck tumors from São Paulo, Brasil. 2014. Master's Dissertation - Universidade de São Paulo (USP). Faculdade de Medicina (FM/SBD) São Paulo.

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