Synthesis, characterization and applications of BODIPY fluorophores.

Abstract

The topical and transdermal drug administration are methods that, in general, avoid patient discomfort and undesirable effects, so several studies in the area of pharmaceutical technology aimed at developing new technologies that increase the effectiveness of topical and transdermal dosage forms, spreading the use of these methods of administration. The use of confocal microscopy in studies on the mechanisms of drug penetration in such dosage forms and on the methods that facilitate this process can provide valuable information. In this study we propose the synthesis of a series of unpublished fluorophore compounds with the boron-dipyrromethene (BODIPY) core with potential application by research groups in pharmaceutical technology area. In partnership with research groups in the area we outlined some BODIPY derivatives so that this project aimed to: synthesize a series of chemically novel BODIPY-derived fluorophores, to evaluate its ability to act as marker for different regions of the skin, and also couple some of these fluorescent compounds with dendrimers to evaluate their application in ocular pharmaceutical formulations.