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Cytotoxicity and antimicrobial potential of essential oil of Casearia Sylvestris and effect of mouthwash formulation with bioactive essential oil on properties of dental restorative materials.

Grant number: 11/23866-8
Support type:Scholarships in Brazil - Doctorate
Effective date (Start): April 01, 2012
Effective date (End): June 30, 2013
Field of knowledge:Health Sciences - Dentistry - Dental Materials
Principal researcher:Alma Blasida Concepcion Elizaur Benitez Catirse
Grantee:Ana Paula Terossi de Godoi
Home Institution: Faculdade de Odontologia de Ribeirão Preto (FORP). Universidade de São Paulo (USP). Ribeirão Preto , SP, Brazil


Some studies have been done on the association of dental restorative materials and antiseptic solutions, therefore, particularly chlorhexidine (CHX), and the benefits have side effects. Thus become necessary to study alternative solutions as effective as the CHX, but without these side effects.Thus, researchers will look at Casearia Sylvestris (CS), is a medicinal plant and provides many benefits, but, however, little is known about the effect of these restorative materials (MR) and some doubts remain about its potential antimicrobial and their toxicity on cells. The objective of this study is to evaluate the biological properties of essential oil and the effect of CS on MR. Will be obtained essential oil from CS, determined the minimum inhibitory concentrations and bactericidal these, compared to the species Streptococcus (mutans, mitis, and salivarius sanguinis) and Enterococcus faecalis compared to CHX.For the evaluation of surface roughness, color, hardness, qualitative analysis of the surface (SEM) and chemical (fluorescence spectrometry X-rays), MR submitted to the solutions under study, 90 specimens will be made (n = 10), 30 of each MR (composite, glass ionomer cement and ceramics), which will be divided into 3 groups to be submitted: G1 - CHX, G2 - Essential oil of CS and G4 - Distilled. Readings will be held with the appropriate apparatus, after polishing of specimens and 24 hours after the end of the trial period. The results will be evaluated according to the classical statistical concepts, after exploratory data analysis.

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Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
AMANDA HENRIQUES CAVALHEIRO; ANA PAULA TEROSSI GODOI; TATIANE CRUZ DE CARVALHO; ALMA BLASIDA CATIRSE; NIEGE ARAÇARI JACOMETTI CARDOSO FURTADO. Antimicrobial potential of Casearia sylvestris against oral bacteria. Rev. odontol. UNESP, v. 45, n. 4, p. 214-218, Ago. 2016.
Academic Publications
(References retrieved automatically from State of São Paulo Research Institutions)
GODOI, Ana Paula Terossi de. Study of CS essential oil and Formulation of mouthwash. Chemical characterization, cytotoxicity, and antimicrobial potentia, effect on the properties of Dental Materials aesthetic.. 2013. Doctoral Thesis - Universidade de São Paulo (USP). Faculdade de Odontologia de Ribeirão Preto Ribeirão Preto.

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