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Isolation, identification and mechanism of action of fractions and active principles of Boehmeria caudata Sw with anticancer activity.

Grant number: 11/22458-3
Support type:Scholarships in Brazil - Doctorate
Effective date (Start): March 01, 2012
Effective date (End): February 29, 2016
Field of knowledge:Biological Sciences - Pharmacology - General Pharmacology
Principal researcher:João Ernesto de Carvalho
Grantee:Paula Pereira de Paiva
Home Institution: Centro Pluridisciplinar de Pesquisas Químicas, Biológicas e Agrícolas (CPQBA). Universidade Estadual de Campinas (UNICAMP). Paulínia , SP, Brazil


Cancer is the second cause of death in developed and developing countries. The progressive increasing of case number makes clear the need of continuous development of new chemotherapeutic. About 60% of anticancer drugs are derived from natural products, demonstrating the great potential of these products in research and development of new anticancer drugs. Thus, based on a project BIOPROSPECTA - FAPESP which aimed the evaluation of antiproliferative activity of medicinal plants used by population of a protected area of Serra da Mantiqueira Paulista, a master's degrees project was developed in order to evaluate two species of Boehmeria genus. Between these two species, the ethanolic extract of B. caudata showed the best antiproliferative activity profile for most human tumor lines studied, with cytotoxic effects at concentrations in the order of 0.25 µg/mL. Moreover, from this extract, a mixture of alkaloids was isolated which presented a very good antiproliferative profile in vitro. Based on these results, this project aims to continuing B. caudata antiproliferative evaluation by isolation of active compounds, evaluation of its anticancer activity in vivo and determination of their possible mechanism of action.

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Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
DE PAIVA, PAULA P.; NUNES, JULIA H. B.; NONATO, FABIANA R.; RUIZ, ANA L. T. G.; ZAFRED, RAFAEL R. T.; SOUSA, ILZA M. O.; OKUBO, MARCIA Y.; KAWANO, DANIEL F.; MONTEIRO, PAULA A.; FOGLIO, MARY A.; CARVALHO, JOAO E. In Silico, In Vitro, and In Vivo Antitumor and Anti-Inflammatory Evaluation of a Standardized Alkaloid-Enriched Fraction Obtained fromBoehmeria caudataSw. Aerial Parts. Molecules, v. 25, n. 17 SEP 2020. Web of Science Citations: 0.
Academic Publications
(References retrieved automatically from State of São Paulo Research Institutions)
PAIVA, Paula Pereira de. Evaluation of antitumor and anti-inflammatory activity of phenanthroquinolizidines alkaloids rich fraction of Boehmeria caudata Sw.. 2016. 214 f. Doctoral Thesis - Universidade Estadual de Campinas (UNICAMP). Instituto de Biologia.

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Filed patent(s) as a result of this research project

COMPOSIÇÃO FARMACÊUTICA E SEU USO BR1020170182401 - Universidade Estadual de Campinas (UNICAMP) . Mary Ann Foglio; Glyn Mara Figueira; Ilza Maria de Oliveira Sousa; João Ernesto de Carvalho; Sirlene Valerio Tinti; Rafael Rosolen Teixeira Zafred ; Ana Lúcia Tasca Gois Ruiz; Fabiana Regina Nonato; Paula Pereira de Paiva - August 2017, 25