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Search of causal polymorphisms in candidate genes previously indicated by genomic analyses and their association with sexual precocity in Nellore heifers

Grant number: 11/22021-4
Support type:Scholarships in Brazil - Doctorate
Effective date (Start): March 01, 2012
Effective date (End): July 31, 2015
Field of knowledge:Agronomical Sciences - Animal Husbandry - Genetics and Improvement of Domestic Animals
Principal researcher:Humberto Tonhati
Grantee:Gregório Miguel Ferreira de Camargo
Home Institution: Faculdade de Ciências Agrárias e Veterinárias (FCAV). Universidade Estadual Paulista (UNESP). Campus de Jaboticabal. Jaboticabal , SP, Brazil
Associated scholarship(s):13/12851-5 - Genic expression to study puberty and fertility in Brahman cattle, BE.EP.DR


In beef cattle production, the sexual precocity is a trait with a big importance because of the high economic value associated to it, being three times more important, in genetic-economic values, than growth traits. The genetic parameters are interesting, because it has high heritability values, permitting selection. However, in genomic analyses, is difficult to find the balance between applying a conservative or a relaxed threshold model, so new methodologies were proposed to find genes of interest using previous genomic analyses. So, it is proposed to investigate causal polymorphisms in these genes previously indicated as candidates (NCOA2 and TOX) as well as others (JY-1) and establish a possible association with sexual precocity in Nellore heifers. (AU)

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Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
DE CAMARGO, GREGORIO M. F.; COSTA, RAPHAEL B.; DE ALBUQUERQUE, LUCIA G.; REGITANO, LUCIANA C. A.; BALDI, FERNANDO; TONHATI, HUMBERTO. Polymorphisms in TOX and NCOA2 genes and their associations with reproductive traits in cattle. REPRODUCTION FERTILITY AND DEVELOPMENT, v. 27, n. 3, p. 523-528, . (11/22021-4)
Academic Publications
(References retrieved automatically from State of São Paulo Research Institutions)
CAMARGO, Gregório Miguel Ferreira de. Mutações putativo-causais em genes candidatos associadas à fertilidade de bovinos de corte e bubalinos. 2015. Doctoral Thesis - Universidade Estadual Paulista (Unesp). Faculdade de Ciências Agrárias e Veterinárias. Jaboticabal Jaboticabal.

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