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Clinical aproach of premature lambs: evaluation of emergencial protocols for terapeutic stimulation of the respiartory activity

Grant number: 11/18814-9
Support Opportunities:Scholarships in Brazil - Doctorate
Effective date (Start): March 01, 2012
Effective date (End): January 31, 2015
Field of knowledge:Agronomical Sciences - Veterinary Medicine - Animal Clinics and Surgery
Principal Investigator:Luiz Claudio Nogueira Mendes
Grantee:Fernanda Bovino
Host Institution: Faculdade de Medicina Veterinária (FMVA). Universidade Estadual Paulista (UNESP). Campus de Araçatuba. Araçatuba , SP, Brazil


The aim of the work is to evaluate the effectiveness of different therapeutical protocols in premature lambs to stimulate the respiratory activity. The animals will be divided in five groups with at least five animals each. That each group will receive a different treatment, with exception of group I that will be constituted by lamb in a term (145 days) and group II that it will be of premature lambs without any intervention. The lambs that will constitute group I will be born of normal delivery and the other prematures lambs will be born by cesarean section. Physical evaluation and termography will be realized immediately after the birth, at 60 minutes, at six, at 12, at 24 and at 48 hours after the born. The blood samples will be collect in these same moments and realize of the blood gas analysis, complete blood count, liver and kidney profile, glucose, lactate, cortisol, insulina and determination of protein fractions by polyacrylamide gel electrophoresis. The pulmonary patern is to evaluate will be conducted radiographic examination at immediately born, at 24 and at 48 hours of life. The variable will be submitted to the variance analysis (ANOVA), to determine if it has difference between the groups and the moments, with level of significance of 5%.

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Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
BOVINO, F.; DENADAI, D. S.; AVILA, L. G.; DESCHK, M.; SANTOS, P. S. P.; FEITOSA, F. L. F.; PEIRO, J. R.; MENDES, L. C. N.. Influência da dexametasona e do surfactante na vitalidade e na função pulmonar de cordeiros prematuros nascidos por cesariana eletiva. Arquivo Brasileiro de Medicina Veterinária e Zootecnia, v. 71, n. 1, p. 44-52, . (11/18810-3, 12/22897-0, 11/18814-9)
Academic Publications
(References retrieved automatically from State of São Paulo Research Institutions)
BOVINO, Fernanda. Abordagem clínica de cordeiros prematuros: avaliação de protocolos terapêuticos emergenciais para estimulação da atividade respiratória. 2015. Doctoral Thesis - Universidade Estadual Paulista (Unesp). Faculdade de Medicina Veterinária. Araçatuba Araçatuba.

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