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Campomanesia adamantium and Campomanesia guaviroba: Phytochemical Study and Evaluation of Biological Activities in vitro and in vivo.

Grant number: 11/17067-5
Support Opportunities:Scholarships in Brazil - Doctorate
Effective date (Start): March 01, 2012
Effective date (End): February 28, 2015
Field of knowledge:Health Sciences - Pharmacy - Pharmacognosy
Principal Investigator:Marcos José Salvador
Grantee:Aislan Cristina Rheder Fagundes Pascoal
Host Institution: Instituto de Biologia (IB). Universidade Estadual de Campinas (UNICAMP). Campinas , SP, Brazil


In this study we propose to study the search for antiproliferative drug accumulated in the ethanol extract from leaves of Campomanesia adamantium and Campomanesia guaviroba (Myrtaceae). For this purpose, the methodology will be suitable for in vitro evaluation of antiproliferative activity against human tumor cell lines and the study will be used in vivo model of Ehrlich tumor. The phytochemical study will aim at identifying the major constituents assets. Initially we will get the profile of the active extracts (TLC, HPLC, ESI-MS/MS), allowing the identification of some substances known directly in crude extracts. The substances cannot be identified in first step,we will be submitted extracts to fractionation, guided by antiproliferative activity.The substances isolated and purified will be held structural elucidation using spectroscopic analysis (UV, IR, NMR (1D and 2D) ESI-MS/MS). The fractions that are experiencing the best antiproliferative activity against cell lines will be tested in vivo. Thus, the study will be conducted with C. adamantium and C. Guaviroba to search for substances with antiproliferative activity, to obtain new sources of pharmaceutical ingredients.

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Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
TOMASIN, REBEKA; RHEDER FAGUNDES PASCOAL, AISLAN CRISTINA; SALVADOR, MARCOS JOSE; CINTRA GOMES-MARCONDES, MARIA CRISTINA. Aloe veraand Honey Solution and Their Ethanolic Extraction Solution Could Act on Metastasis-Regulating Processes in Walker 256 Tumor Tissues In Vivo?. NUTRITION AND CANCER-AN INTERNATIONAL JOURNAL, v. 73, n. 7, . (10/00714-5, 10/00209-9, 14/13334-7, 17/02739-4, 11/17067-5, 15/03726-8)
Academic Publications
(References retrieved automatically from State of São Paulo Research Institutions)
PASCOAL, Aislan Cristina Rheder Fagundes. Campomanesia adamantium and Campomanesia guaviroba: phytochemistry and in vitro and in vivo studies in order to determine the biological activity and toxicit. 2015. Doctoral Thesis - Universidade Estadual de Campinas (UNICAMP). Instituto de Biologia Campinas, SP.

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