Chemical Study of the endophytic microbiota from Vochysia divergens and evaluation of its schistossomicidal potential.

Abstract

This cientific iniciation project intends to realize the chemistry study of endophytic microbiota of Vochysia divergens Pohl (Vochysiaceae), a native food species from Pantanal Biome. This region has been selected for study within the Regular Research Project "Bioactive compounds from medicinal and food plants of the Cerrado and Pantanal and their endophytic microbiota (Fapesp Process # 2011/00631-5).The phytochemistry researches will be bioassay-guided by the schistosomicidal in vitro assay. The schistosomicidal test will be held evaluating the life cycle of Schistosoma mansoni vector. The analytical methodologies will employ chromatography techniques (CC, PTLC, GC-MS, HPLC-DAD). The chemical structures of the isolated compounds will the assign on the bases of 1D and 2D NMR experiments. Thus, the main goal of this proposal will be identify the potential schistossomicidal of natural compounds, as well as contribute to the human resource formation in the natural product area in the country.