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In vitro evaluation of adhesion molecules expression on in situ like neoplastic malignant areas under tumoral microenvironment influence

Grant number: 11/19082-1
Support type:Scholarships in Brazil - Scientific Initiation
Effective date (Start): February 01, 2012
Effective date (End): January 31, 2013
Field of knowledge:Health Sciences - Dentistry
Principal researcher:Elizabeth Ferreira Martinez
Grantee:Natalia Festugatto Navarini
Home Institution: Centro de Pesquisas Odontológicas São Leopoldo Mandic. Faculdade São Leopoldo Mandic (SLMANDIC). Sociedade Regional de Ensino e Saúde S/S Ltda (SRES). Campinas , SP, Brazil


The tumor microenvironment, during the development of the neoplastic process, has been studied, especially in breast cancer, and is considered a determinant factor in the behavior of cancer. Among all the components involved in the tumor microenvironment, the stromal cells represented by the my epithelial cells in gland tumors have an important role. Pleomorphic adenoma awakens interest in the study of tumors, for being the most common tumor gland and one of the few benign neoplasms that can undergo malignant transformation, sometimes mediated by my epithelial cells. Besides, the extracellular matrix and growth factors can regulate the proliferation and differentiation of these cells contributing to metastasis. Thus, the objective of this study is to evaluate cell-cell and cell-matrix interactions in areas that represent a situation when in situ squamous cell carcinoma of the malignant cells are surrounded by benign my epithelial cells of pleomorphic adenoma, under the influence of an extracellular matrix protein, collagen type I and epidermal growth factor (EGF), and thus stimulating the condition of the tumor microenvironment at different times, in order to identify the moment and presence of expression of these proteins in the neoplastic process. It will be assessed by indirect immunofluorescence the immunoexpression of ±2²1 integrin protein, E-cadherin, and ²-catenin in the areas that simulate the in situ condition.(AU)

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Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
NAVARINI, NATALIA FESTUGATTO; DE ARAUJO, VERA CAVALCANTI; BROWN, AMY LOUISE; PASSADOR-SANTOS, FABRICIO; DE SOUZA, ISABELA FERNANDES; NAPIMOGA, MARCELO HENRIQUE; ARAUJO, NEY SOARES; MARTINEZ, ELIZABETH FERREIRA. The EGF signaling pathway influences cell migration and the secretion of metalloproteinases by myoepithelial cells in pleomorphic adenoma. TUMOR BIOLOGY, v. 36, n. 1, p. 205-211, . (11/19082-1)

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