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Genomic Profiling of Messenger RNAs and MicroRNAs in muscle cells treated in vitro with TNF-alpha and IFN-gamma

Grant number: 11/16282-0
Support Opportunities:Scholarships in Brazil - Master
Effective date (Start): March 01, 2012
Effective date (End): September 30, 2013
Field of knowledge:Biological Sciences - Morphology - Histology
Principal Investigator:Robson Francisco Carvalho
Grantee:Geysson Javier Fernandez Garcia
Host Institution: Instituto de Biociências (IBB). Universidade Estadual Paulista (UNESP). Campus de Botucatu. Botucatu , SP, Brazil
Associated scholarship(s):13/02005-0 - Reconstruction of gene regulation networks involved in cancer cachexia: integrating expression profiles of microRNAs and mRNA, BE.EP.MS


The skeletal muscle atrophy is a common phenomenon in many chronic systemic diseases such a sepsis, chronic heart failure, chronic obstructive pulmonary disease, chronic kidney disease, diabetes, AIDS and cancer. These diseases may be accompanied by a complex metabolic syndrome characterized by muscle wasting, denominated cachexia. The molecular pathways responsible for cachexia are not completely understood, however, evidence suggest that pro-inflammatory cytokines like Tumor Necrosis Factor (TNF)-± and Interferon (INF)-³ have a key role in molecular pathways related to loss of function and muscle mass. The complexity of mechanisms controlling gene expression in this process suggests the involvement of additional regulatory molecules, such as microRNAs; these RNA molecules encoded by the genome regulate the function of skeletal muscle during development and various muscle diseases. MicroRNAs orchestrate common pathways or biological function, this unique feature gives rise as an effective tool for determining the pathways involved in specific diseases or biological processes. The hypothesis of this work is that the muscle atrophy induced by TNF-± and INF-³ has a microRNAs expression profile that will allow the identification of regulatory networks and molecular pathways

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Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
FERNANDEZ, GEYSSON JAVIER; FERREIRA, JUAREZ HENRIQUE; VECHETTI JR, IVAN JOSE; DE MORAES, LEONARDO NAZARIO; CURY, SARAH SANTILONI; FREIRE, PAULA PACCIELLI; GUTIERREZ, JAYSON; FERRETTI, RENATO; DAL-PAI-SILVA, MAELI; ROGATTO, SILVIA REGINA; et al. MicroRNA-mRNA Co-sequencing Identifies Transcriptional and Post-transcriptional Regulatory Networks Underlying Muscle Wasting in Cancer Cachexia. FRONTIERS IN GENETICS, v. 11, . (13/02005-0, 12/13961-6, 13/50343-1, 16/08294-1, 14/13941-0, 11/16282-0)
Academic Publications
(References retrieved automatically from State of São Paulo Research Institutions)
GARCIA, Geysson Javier Fernandez. Reconstruction of molecular networks involved in citokine-induced myotubes atrophy integrating microRNA and mRNA expression. 2013. Master's Dissertation - Universidade Estadual Paulista (Unesp). Instituto de Biociências. Botucatu Botucatu.

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