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Aortic lipid infiltration in renovascular hypertensive hyperlipidemic mice elicited by dietary sodium chloride restriction improves by losartan and hydralazine

Grant number: 11/16164-7
Support type:Scholarships in Brazil - Master
Effective date (Start): March 01, 2012
Effective date (End): February 28, 2014
Field of knowledge:Health Sciences - Medicine - Medical Clinics
Principal researcher:Sergio Catanozi
Grantee:Fernanda Bueno Fusco
Home Institution: Faculdade de Medicina (FM). Universidade de São Paulo (USP). São Paulo , SP, Brazil


Changes in lipid as well as carbohydrate metabolism has been shown in the presence of sodium chloride restriction. Hyperlipidemia and the renin-angiotensin system association increases aterogenic process. In this sense, angiotensina II (ANGII) binding to AT1 receptor has been associated to increased lipid infiltration into arterial wall, reactive oxygen species and advanced glycation end products generation, monocyte adhesion in endothelial cells and oxidized-low density lipoprotein (LDL) uptake by macrophage. In this study, experiments are going to be carried out on LDL receptor knockout mice (LDLR KO) on a low salt diet (LS; 0.15% NaCl), as compared with a normal salt diet (NS; 1.27% NaCl). Insertion of a renal artery clip and antihypertensive treatments are going to be carried out in ten-week-old mice. Mice fed LS diet are going to be assigned to groups that receive either losartan (LS+losartan) or hydralazine hydrochloride (LS+hydralazine). The control groups (SHAM) are going to be fed LS or NS diet without both the insertion of renal artery clip and antihypertensive treatment. After 5 months of age, the following parameters will be measured: plasma triglyceride, cholesterol, free fatty acids and aldosterona concentrations, urinary sodium, renal rennin activity, blood pressure, lipid infiltration and macrophage receptor expression in the aortic arch. Thus, it will be possible evaluate early atherosclerotic changes in the vascular wall and relate them to blood pressure and lipemia in hyperlipidemic hypertensive mice fed a low salt diet.

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Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
GOMES, DIEGO JUVENAL; VELOSA, ANA PAULA; OKUDA, LIGIA SHIMABUKURO; FUSCO, FERNANDA BUENO; DA SILVA, KAROLINNE SANTANA; PINTO, PAULA RAMOS; NAKANDAKARE, EDNA REGINA; CORREA-GIANNELLA, MARIA LUCIA; WOODS, TOM; BRIMBLE, MARGARET ANNE; et al. Glycated albumin induces lipid infiltration in mice aorta independently of DM and RAS local modulation by inducing lipid peroxidation and inflammation. JOURNAL OF DIABETES AND ITS COMPLICATIONS, v. 30, n. 8, p. 1614-1621, . (13/11084-0, 11/04631-0, 12/19755-9, 11/16164-7, 13/02854-7, 13/23392-1)
FUSCO, FERNANDA B.; GOMES, DIEGO J.; BISPO, KELY C. S.; TOLEDO, VERONICA P.; BARBEIRO, DENISE F.; CAPELOZZI, VERA L.; FURUKAWA, LUZIA N. S.; VELOSA, ANA P. P.; TEODORO, WALCY R.; HEIMANN, JOEL C.; et al. Low-sodium diet induces atherogenesis regardless of lowering blood pressure in hypertensive hyperlipidemic mice. PLoS One, v. 12, n. 5, . (11/04631-0, 11/16164-7, 13/11084-0, 12/19755-9)
Academic Publications
(References retrieved automatically from State of São Paulo Research Institutions)
FUSCO, Fernanda Bueno. Aortic lipid infiltration in renovascular hypertensive hyperlipidemic mice elicited by dietary sodium chloride restriction improves by losartan and hydralazine. 2015. Master's Dissertation - Universidade de São Paulo (USP). Faculdade de Medicina (FM/SBD) São Paulo.

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