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Expression of dependent-cyclin kinase (Cdks 1, 2, 4 e 6) on pancreatic islets of NOD mouse (non-obese diabetic) treated with leaves aqueous extract of Passiflora alata

Grant number: 11/15763-4
Support Opportunities:Scholarships in Brazil - Master
Effective date (Start): March 01, 2012
Effective date (End): June 30, 2013
Field of knowledge:Health Sciences - Medicine - Medical Clinics
Principal Investigator:Ricardo de Lima Zollner
Grantee:Daniella de Figueiredo
Host Institution: Faculdade de Ciências Médicas (FCM). Universidade Estadual de Campinas (UNICAMP). Campinas , SP, Brazil


The search for new drugs from medicinal plants has motivated the research for alternative substances with potential anti-inflammatory that could aid in the treatment of inflammatory diseases, as in the case of type 1 diabetes. As a tool to study these substances that modulate inflammation, is common to use animals with a susceptibility to develop diabetes, as NOD mice. The literature, not always indexed, suggest that the Passiflora sp has a hypoglycemic property improving the diabetes control. Among the Passiflora components, the alkaloids and flavonoids are the relevant candidates. After a preliminary study follow by the same protocol that diacerhein and gangliosides treatment, the results caught our attention with reference to decreased expression of diabetes and degree of injury to the islet. Moreover, the Passiflora sp is a natural food with easy access for consume and consequently studies of biological properties and its use in some inflammatory diseases. Thus, this study aims to evaluate in NOD mice the effects of Passiflora alata on the islet inflammatory process, cells phenotyping and in particular cell cycle factors expression cyclin-dependent kinases (Cdks) 1, 2, 4 and 6 that could be associated to inflammation control and cellular regeneration leading to reduction of diabetes. Moreover, to invest in the development of new drugs with potential to interfere with the development of diabetes. (AU)

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Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
FIGUEIREDO, D.; COLOMEU, TALITA CRISTINA; GONZALEZ SCHUMACHER, NAYARA SIMON; STIVANIN-SILVA, L. G.; BETIM CAZARIN, CINTHIA BAU; MOLINA MELETTI, LAURA MARIA; ROMANI FERNANDES, LUIS GUSTAVO; PRADO, MARCELO ALEXANDRE; ZOLLNER, R. L.. Aqueous leaf extract of Passiflora alata Curtis promotes antioxidant and anti-inflammatory effects and consequently preservation of NOD mice beta cells (non-obese diabetic). International Immunopharmacology, v. 35, p. 127-136, . (11/06559-4, 13/25256-8, 11/15763-4)
Academic Publications
(References retrieved automatically from State of São Paulo Research Institutions)
FIGUEIREDO, Daniella de. Cyclin-dependent kinase expression (Cdks 1, 2, 4 e 6) in pancreatic islets of NOD mice (non-obese diabetic) treated with Passiflora alata leaves aqueous extract. 2014. Master's Dissertation - Universidade Estadual de Campinas (UNICAMP). Faculdade de Ciências Médicas Campinas, SP.

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