The incidence of hypertension, insulin resistance, type 2 diabetes and the morbidity and mortality increased after the menopause event. On the other hand, aerobic exercise training has been recommended as an important therapy for the prevention and treatment of cardio-metabolic disorders, according to the recognized benefits of this approach in different populations. Recently, resistance exercise training has been recommended in addition to aerobic training (combined training) in the treatment of cardiovascular and metabolic diseases, however, little is known about the physiological benefits of this approach. In addition, the mechanisms involved in the possible benefits of combined dynamic exercise training were not well studied after ovarian hormone deprivation, especially in the presence of cardio-metabolic disorders. Thus, the purpose of this study is to investigate the effects of combined dynamic exercise training in hypertensive ovariectomized rats submitted to fructose overload. The rats will be divided into 6 groups: control Wistar rats (SC); and spontaneously hypertensive rats (SHR) submitted (SHO) or not (SH) to the ovarian hormone deprivation, SHR ovariectomized chronic treated with fructose sedentary (SHOF) or trained (CHOF). The combined exercise training will be conducted on a treadmill and stair adapted to rats, on alternate days. Parameters of cardiovascular function (blood pressure, BP, and heart rate, HR), cardiovascular autonomic modulation (heart rate and blood pressure variability and baroreflex sensitivity), metabolic (body weight, adipose tissue, blood glucose and triglycerides, insulin tolerance) and exercise capacity (maximal running test on treadmill and maximal load test on stair), and their relationship with parameters of oxidative stress (lipid peroxidation by chemiluminescence; redox balance by oxidized glutathione/reduced gluthatione ratio; carbonylated proteins; production of superoxide anion and hydrogen peroxide; catalase, glutathione peroxidase and superoxide dismutase activities; and total antioxidant capacity), nitric oxide metabolism (plasmatic nitrite and nitrate concentrations) and inflammation (leptin, adiponectin, TNF alpha, IL-6 and IL -10) will be evaluated. The results of this study will contribute to a better understanding of the mechanisms involved in the association of risk factors in women as well as to verify the effects of combined exercise training in a model that associated ovarian hormone deprivation and cardio-metabolic disorders.
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