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In vivo comparison of biocompatibility of porous surface samples made with different titanium alloys

Grant number: 11/15342-9
Support Opportunities:Scholarships in Brazil - Master
Effective date (Start): March 01, 2012
Effective date (End): February 28, 2014
Field of knowledge:Health Sciences - Dentistry
Principal Investigator:Luana Marotta Reis de Vasconcellos
Grantee:Evelyn Luzia de Souza Santos
Host Institution: Instituto de Ciência e Tecnologia (ICT). Universidade Estadual Paulista (UNESP). Campus de São José dos Campos. São José dos Campos , SP, Brazil


Today, the implantology concentrates in studies that target and enable the more rapid osseointegration of surgical implants. The aim of this study will be to compare the bone neoformations into porous surface samples, made of different titanium (Ti) alloys. Also, we will correlate the structural properties of the different titanium alloys with the bone neoformations obtained in the porous samples. By means of powder metallurgy, 75 samples exhibiting dense core integrated to the porous surface, will be made and divided into five groups: a) group 1: control - commercially pure titanium; b) group 2: Ti-6Al-4V alloy (titanium-aluminium-vanadium); c) group 3: Ti-13Nb-13Zr alloy (titanium-niobium-zirconium); d) group 4: Ti-35Nb alloy (niobium); e) group 5: Ti-35Nb-7Zr-5Ta alloy (titanium-niobium-zirconium-tantalum). Five samples of each group will be submitted to chemical, morphological and mechanical characterization. In this study fifteen rabbits will be used to evaluate and to compare the bone neoformation obtained in the porous surface samples by means of histological and histomorphometric analyses and also by the use of fluorescent markers. Each rabbit will receive one sample of each group and the G1, G2, G3 samples will be inserted into the right tibiae and the G4, G5 samples in the left tibiae. Five rabbits, randomly selected, will be euthanized 2, 4 and 8 weeks after the surgery. The data will be evaluated by the ANOVA statistical test and if necessary a Tukey multiple comparison test of Tukey will be used(p <0.05).

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Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
DO PRADO, RENATA FALCHETE; ESTEVES, GABRIELA CAMPOS; DE SOUZA SANTOS, EVELYN LUZIA; GRITI BUENO, DAIANE ACACIA; ALVES CAIRO, CARLOS ALBERTO; OLIVEIRA DE VASCONCELLOS, LUIS GUSTAVO; SAGNORI, RENATA SILVEIRA; PEREIRA TESSARIN, FERNANDA BASTOS; OLIVEIRA, FELIPE EDUARDO; DE OLIVEIRA, LUCIANE DIAS; et al. In vitro and in vivo biological performance of porous Ti alloys prepared by powder metallurgy. PLoS One, v. 13, n. 5, . (12/20311-8, 11/23662-3, 11/15342-9, 12/13338-7, 12/13324-6, 12/22158-2)
Academic Publications
(References retrieved automatically from State of São Paulo Research Institutions)
SANTOS, Evelyn Luzia de Souza. Comparação in vivo da biocompatilidade de amostras com superfície porosa confeccionadas com diferentes ligas de titânio. 2014. Master's Dissertation - Universidade Estadual Paulista (Unesp). Instituto de Ciência e Tecnologia. São José dos Campos São José dos Campos.

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