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Inflammatory mediators in overweight pregnant women and the risk of gestational diabetes mellitus

Grant number: 11/14620-5
Support Opportunities:Scholarships in Brazil - Master
Effective date (Start): March 01, 2012
Effective date (End): May 31, 2013
Field of knowledge:Health Sciences - Medicine - Maternal and Child Health
Principal Investigator:Silvia Daher
Grantee:Thalita Frutuoso Lobo
Host Institution: Escola Paulista de Medicina (EPM). Universidade Federal de São Paulo (UNIFESP). Campus São Paulo. São Paulo , SP, Brazil


Gestational diabetes mellitus (GDM) is defined as glucose intolerance of variable severity, which appeared or was diagnosed during pregnancy. The incidence of overweight reproductive age women is increasing significantly throughout the world, raising the risks for GDM and other obstetric complications. Investigations on the association gestation/obesity/GDM have been focused primarily on epidemiological and clinical aspects. Although the pathophysiological mechanisms involved in the development of GDM in overweight women are still not clear, it seems that inflammatory response plays a central role. Molecules such as adiponectin, leptin, resistin, visfatin, C-reactive protein and ghrelin are noted for being strongly associated with the mechanism of insulin resistance and overweight.Inflammatory mediators have been implicated in the pathophysiology of GDM, however, there are no known predictive markers for this disorder. The objective of this study is to identify predictive biomarkers for DMG in overweight women in the first half of pregnancy. To achieve this aim, we will follow a cohort of overweight pregnant women to assess whether changes in serum levels of adiponectin, leptin, resistin, visfatina, C reactive protein and ghrelin in the first half of gestation precede the later development of GDM.

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