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Crohn's disease: effect of nutrition supplements on Disease Activity Index (CDAI) and nutritional state of the patients in therapy with anti-TNF-alpha and Azathioprine.

Grant number: 11/04750-9
Support Opportunities:Scholarships in Brazil - Master
Effective date (Start): March 01, 2012
Effective date (End): July 31, 2013
Field of knowledge:Health Sciences - Medicine - Maternal and Child Health
Principal Investigator:Maria Marluce dos Santos Vilela
Grantee:Júlia Figueiredo Machado
Host Institution: Faculdade de Ciências Médicas (FCM). Universidade Estadual de Campinas (UNICAMP). Campinas , SP, Brazil


Crohn's disease (CD) is a chronic inflammatory disease that may affect any part of the gastrointestinal tract. During the acute phase, the digestive symptoms can lead to malnutrition, which often complicate the disease. However, in the disease remission phase some patients show overweight or obesity; adipose tissue produces pro-inflammatory cytokines, that can make disease problems worse. Reports showed that bovine whey protein may improve body composition (increase lean tissue and decrease adipose tissue) and exhibit immunoregulatory effects. The positive effects mentioned and anti-inflammatory outcome from TGF-² cytokine assist in maintenance of disease remission, reducing inflammation and digestive symptoms, providing quality-of-life and enhancing the nutritional status of patients. The present study will evaluate the effects of the application of a supplement composed of bovine whey protein enriched with TGF-² on Crohn's Disease Activity Index (CDAI) and nutritional status of persons with CD. The study will be a prospective, double-blind, placebo-controlled clinical trial. The patients will be randomly split in two groups: one group supplemented with 30g of whey protein concentrate and the other with soy protein isolate (placebo). Supplement compliance will be assessed by means of a questionary applied to each patient in a interview. Nutritional status will be assessed before, during and after the sixteen week supplementation period, by anthropometry, bioimpedance, 24-hour dietary recall and dosage of serum albumin and pre-albumin.

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Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
MACHADO, JULIA FIGUEIREDO; OYA, VANESSA; RODRIGUES COY, CLAUDIO SADDY; MORCILLO, ANDRE MORENO; SEVERINO, SILVANA DALGE; WU, CHAO; SGARBIERI, VALDEMIRO CARLOS; DOS SANTOS VILELA, MARIA MARLUCE. Whey and soy protein supplements changes body composition in patients with Crohn's disease undergoing azathioprine and anti-TNF-alpha therapy. NUTRICION HOSPITALARIA, v. 31, n. 4, p. 1603-1610, . (11/04750-9)
Academic Publications
(References retrieved automatically from State of São Paulo Research Institutions)
MACHADO, Júlia Figueiredo. Doença de Crohn: efeito de suplemento alimentar sobre o estado nutricional de pacientes sob terapia com anti-TNF-alfa e azatioprina. 2013. Master's Dissertation - Universidade Estadual de Campinas (UNICAMP). Faculdade de Ciências Médicas Campinas, SP.

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