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Role of prostaglandins and leukotrienes in dendritic cell functions against Paracoccidioides brasiliensis

Grant number: 11/04556-8
Support Opportunities:Scholarships in Brazil - Master
Effective date (Start): March 01, 2012
Effective date (End): February 28, 2013
Field of knowledge:Biological Sciences - Immunology - Applied Immunology
Principal Investigator:Angela Maria Victoriano de Campos Soares
Grantee:Reginaldo Keller Fernandes
Host Institution: Instituto de Biociências (IBB). Universidade Estadual Paulista (UNESP). Campus de Botucatu. Botucatu , SP, Brazil


The objective of this study is to evaluate if human dendritic cells (DCs) produce PGE2 and LTB4 in response to high and low virulent strains of P.brasiliensis. In addition, the role of pattern recognizing receptors in this production, and the modulatory effect of these eicosanoids in DCs functions will be studied. DCs obtained from monocytes treatment with IL-4 and GM-CSF will be incubated with dectin-1, mannose receptors, TLR2 and DC-SIGN agonists, challenged with high and low virulent strains of P.brasiliensis and evaluated for PGE2 and LTB4 production. In an other set of experiments, DCS were treated with PGE2 and LTB4 inhibitors and evaluated for MHC class II, coestimulatory molecules (CD83, CD80, CD86 and CD40) chemokines receptors (CCR-5, CCR-7 and CXCR-4) expression, and TNF- alfa, IL-6, IL-10 and IL-12 production.

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Academic Publications
(References retrieved automatically from State of São Paulo Research Institutions)
FERNANDES, Reginaldo Keller. Papel de prostaglandinas e leucotrienos sobre as funçoes das células dendrícas em resposta ao Paracoccidioides brasiliensis. 2013. Master's Dissertation - Universidade Estadual Paulista (Unesp). Faculdade de Medicina. Botucatu Botucatu.

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