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Adequacy of folate intake and the effect of flour fortification in pregnant women attended by the National Health System of Ribeirão Preto, Brazil.

Grant number: 11/03781-8
Support Opportunities:Scholarships in Brazil - Master
Effective date (Start): March 01, 2012
Effective date (End): May 31, 2013
Field of knowledge:Health Sciences - Nutrition
Principal Investigator:Daniela Saes Sartorelli
Grantee:Lívia Castro Crivellenti
Host Institution: Faculdade de Medicina de Ribeirão Preto (FMRP). Universidade de São Paulo (USP). Ribeirão Preto , SP, Brazil


Dietary folate intake during pregnancy is crucial given its role on amino acid metabolism, DNA synthesis and cell multiplication. Lower maternal intakes of folate might be associated with adverse health outcomes on the mother and fetus, such as anemia and neural tube defect. National wide recommendation for the use of dietary supplements of folic acid and wheat and maize flour fortification with this nutrient have been adopted in an attempt to prevent these injuries, but the recommended dose of supplement use levels exceed the upper tolerable intake (UL), also representing a harmful condition in pregnancy. The purpose of this study is to estimate the adequacy of folate naturally present in foods and the impact of wheat and maize flour fortification on the adequacy of the folate intake in pregnant women attended by the National Health System of Ribeirão Preto, Brazil. Additionally, we will evaluate the minimum dose of folic acid supplement required to achieve an acceptable prevalence of nutrient adequacy, without exceeding the UL. The data are from a cohort study conducted among 73 adult pregnant women with normal. Dietary folate intake was assessed by 3 24 hours diet recalls, one in each trimester of pregnancy. The adequacy of folate and folic acid intake will be estimated adopting the EAR cut-point method. The estimation of the optimal folic acid supplement dose will be carried out according to the planning approach for the homogenous groups diets, proposed by the DRIs.

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Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
CRIVELLENTI, LIVIA DE CASTRO; BARBIERI, PATRICIA; SARTORELLI, DANIELA SAES. Inadequação de folato na dieta de gestantes. REVISTA DE NUTRICAO-BRAZILIAN JOURNAL OF NUTRITION, v. 27, n. 3, p. 321-327, . (11/03781-8)
Academic Publications
(References retrieved automatically from State of São Paulo Research Institutions)
CRIVELLENTI, Lívia Castro. Estimating of folate in the diet of pregnant women: the role of flour fortification and dietary supplement.. 2013. Master's Dissertation - Universidade de São Paulo (USP). Faculdade de Medicina de Ribeirão Preto (PCARP/BC) Ribeirão Preto.

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