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Baccharis trimera (Less.) DC. essential oil: phytochemical study and in vitro evaluation of antiproliferative and mutagenic activities

Grant number: 11/03540-0
Support Opportunities:Scholarships in Brazil - Master
Effective date (Start): March 01, 2012
Effective date (End): June 30, 2013
Field of knowledge:Health Sciences - Pharmacy - Pharmacognosy
Principal Investigator:Ana Lúcia Tasca Gois Ruiz
Grantee:Adriana Della Torre
Host Institution: Instituto de Biologia (IB). Universidade Estadual de Campinas (UNICAMP). Campinas , SP, Brazil


According to World Health Organization, neoplasias represent the second leading cause of worldwide death. We live in an aerobic environment so all organisms stay continuously and inevitably exposed to reactive oxygen species and/or nitrogen. These species react with DNA, intracellular proteins and lipid from membranes causing damage in these structures; therefore, these damages should be related to the genesis of many chronic diseases, such as cancer. Besides being source of new drugs, plants can also be used in preventing various diseases through different mechanisms of action, such as immunomodulation and antioxidant capacity. Thus, natural products with antioxidant capacity are promising cancer chemopreventive as they can inhibit the occurrence of pre-cancerous lesions in DNA. "Carqueja", Baccharis trimera (Less.) DC. (Asteraceae) is a native species from tropical regions widely used in folk medicine as anti-inflammatory, to treat liver and kidney problems as well as stomach and intestinal disorders. Recent studies have demonstrated the potential of B. trimera essential oil (EO) as schistosomicidal on adult worms of Schistosoma mansoni (BH strain). Since B. trimera presents potential medicinal uses, this project aims to evaluate the antioxidant activity of EO and its fractions on DPPH and Folin-Ciocalteu tests, antimutagenic/mutagenic potential in vitro through the model of micronucleus induction and phytochemical study of the EO in order to correlate chemical composition with the activities. Thus, this study will contribute to the knowledge about pharmacological activity and safety for medicinal use of B. trimera.

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Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
SOBREIRO, MARIANA ALVES; DELLA TORRE, ADRIANA; DE ARAUJO, MARIA ELISA MELO BRANCO; CANELLA, PAULA RENATA BUENO CAMPOS; DE CARVALHO, JOAO ERNESTO; CARVALHO, PATRICIA DE OLIVEIRA; RUIZ, ANA LUCIA TASCA GOIS. Enzymatic Hydrolysis of Rutin: Evaluation of Kinetic Parameters and Anti-Proliferative, Mutagenic and Anti-Mutagenic Effects. LIFE-BASEL, v. 13, n. 2, p. 14-pg., . (11/12394-8, 11/03540-0, 11/01114-4, 09/09224-3, 13/13196-0)
Academic Publications
(References retrieved automatically from State of São Paulo Research Institutions)
TORRE, Adriana Della. Baccharis trimera (Less.) DC. essential oil: phytochemical study and in vitro evaluation of antiproliferative and mutagenic activities. 2013. Master's Dissertation - Universidade Estadual de Campinas (UNICAMP). Instituto de Biologia Campinas, SP.

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