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Biotransformation of kaurenoic acid by filamentous fungi and evaluation of the anti-phytopathogenic properties of the obtained metabolites.

Grant number: 11/21638-8
Support Opportunities:Scholarships in Brazil - Doctorate
Effective date (Start): March 01, 2012
Effective date (End): February 29, 2016
Field of knowledge:Physical Sciences and Mathematics - Chemistry - Organic Chemistry
Principal Investigator:Sergio Ricardo Ambrosio
Grantee:Thiago Sousa Porto
Host Institution: Pró-Reitoria Adjunta de Pesquisa e Pós-Graduação. Universidade de Franca (UNIFRAN). Franca , SP, Brazil
Associated research grant:07/54762-8 - Obtaining structural analogues of pimaradienoic acid through the process of fungal biotransformation and study of the effect of these metabolites on the activity of the TcDHODH enzyme and on the contraction of the vascular smooth muscle of the aorta artery of mice, AP.BTA.JP


The goal of the present project is obtain derivatives from kaurenoic acid (KA), a diterpene found in high amounts in the leaves of Mikania glomerata, which is associated with several biological activities, including its antifungal properties. The structural modifications in the chemical skeleton of KA will be performed by biotransformation processes using two different microorganisms, Aspergillus phoenix and Phomopsis longicolla. The obtained metabolites will be evaluated against a panel of phytopathogens responsible for serious agricultural diseases.

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Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
OLIVEIRA, LARISSA COSTA; PORTO, THIAGO SOUZA; COLMANETTE JUNIOR, ARTHUR HENRIQUE; CONCEICAO SANTOS, MARIO FERREIRA; RAMOS, HENRIQUE PEREIRA; BRAUN, GLAUCIA HOLLAENDER; DE LIMA PAULA, LUCAS ANTONIO; BASTOS, JAIRO KENUPP; JACOMETTI CARDOSO FURTADO, NIEGE ARACARI; TAME PARREIRA, RENATO LUIS; et al. Schistosomicidal activity of kaurane, labdane and clerodane-type diterpenes obtained by fungal transformation. Process Biochemistry, v. 98, p. 34-40, . (11/13630-7, 11/21638-8, 17/02592-3)

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