Application of organometallic reagents in the functionalization of indolizines of synthetic interest

Abstract

Among the heterocycles containing a pyridine ring in their structure, the indolizines are very important because they are commonly found in the structure of substances of medicinal interest. Besides its application against tuberculosis and leishmaniasis, the biological activity of this class of compounds has allowed their use as analgesics, anti-inflammatory, antiviral and antitumor.Although the importance of this class of substances, data in the literature on the direct functionalization indolizines using organometallic bases are rare. Thus, the main objective of this project is to develop a methodology that allows direct functionalization of indolizines using lithium, magnesium and zinc amides. The reaction of the organometallic intermediates with different electrophiles should allow to prepare highly functionalized indolizines.In order to demonstrate the importance of the synthetic methodologies developed, we intend to apply these in the synthesis or structural modification of bioactive indolizines such as STA-5312. In addition, the indolizines that will be synthesized in this project could be tested by the groups of the Faculdade de Ciências Farmacêuticas de Ribeirão Preto - USP dedicated to the biological evaluation of natural and synthetic componds.The proposals presented here are part of the project "Development of New Synthetic Methods Aiming Preparation of Bioactive Molecules", approved by FAPESP through the Young Researcher Program with the objective to give support to research groups acting on modern themes with international impact. (AU)