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Effect of photodynamic therapy on superficial demineralization of bovine enamel and root dentin in vitro

Grant number: 11/13328-9
Support Opportunities:Scholarships in Brazil - Scientific Initiation
Effective date (Start): January 01, 2012
Effective date (End): December 31, 2012
Field of knowledge:Health Sciences - Dentistry - Dental Clinics
Principal Investigator:Carla Andreotti Damante
Grantee:Paula Ducati
Host Institution: Faculdade de Odontologia de Bauru (FOB). Universidade de São Paulo (USP). Bauru , SP, Brazil


Antimicrobial photodynamic therapy has been used in dentistry for bacterial elimination on root canal, periodontal pocket and treatment of periimplantitis. It is a safe technique, but we observed clinically a superficial demineralization on enamel and dentine hypersensitivity after its application on dental crowns. The aim of this study is to evaluate if photodynamic therapy with toluidine blue O causes superficial demineralization on bovine enamel and radicular dentin. Enamel and root dentin blocks will be divided in four groups: control (without treatment), photodynamic therapy (dye pH3), photodynamic therapy (dye pH5), citric acid (pH1). Laser used for photodynamic therapy will be red (660nm), 45J/cm², 30mW. Punctual mode associated to toluidine blue. Microhardness Knoop will be evaluated by a microhardness tester and surface profile of enamel and dentin will be obtained by a contact profilometer. The statistical analysis will be realized at a significance level of 5% (P<0,05). ANOVA test complemented by Tukey will be used if the sample presents normal distribution. If the distribution is not normal Kruskall-Wallis complemented by Dunn tests will be used. (AU)

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Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
DAMANTE, CARLA ANDREOTTI; DUCATI, PAULA; FERREIRA, RAFAEL; SALMERON, SAMIRA; RAGGHIANTI ZANGRANDO, MARIANA SCHUTZER; RUBO DE REZENDE, MARIA LUCIA; PASSANEZI SANT'ANA, ADRIANA CAMPOS; AGUIAR GREGHI, SEBASTIDO LUIZ; MAGALHAES, ANA CAROLINA. In vitro evaluation of adhesion/proliferation of human gingival fibroblasts on demineralized root surfaces by toluidine blue O in antimicrobial photodynamic therapy. Photodiagnosis and Photodynamic Therapy, v. 13, p. 303-307, . (12/06738-9, 11/13328-9)

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