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Evaluation of epigenetic and immune alterations of macrophages from patients infected with human immunodeficiency virus in response to Mycobacterium tuberculosis

Grant number: 11/12512-0
Support Opportunities:Scholarships in Brazil - Doctorate
Effective date (Start): March 01, 2012
Effective date (End): June 30, 2015
Field of knowledge:Biological Sciences - Immunology - Applied Immunology
Principal Investigator:Fabiani Gai Frantz
Grantee:Milena Sobral Espíndola
Host Institution: Faculdade de Ciências Farmacêuticas de Ribeirão Preto (FCFRP). Universidade de São Paulo (USP). Ribeirão Preto , SP, Brazil

Abstract

In developing countries including Brazil, the HIV-1 infection is a major cause of death attributed to infectious diseases, especially when associated with opportunistic coinfections, such as tuberculosis, which affects one third of patients infected with HIV. Macrophages have an essential role in both diseases, they are the reservoir and site of intracellular growth of both pathogens, in addition, they are key cells to the elimination of Mycobacterium tuberculosis. However, several studies show that HIV infection reduces the viability of macrophages, deregulates the proinflammatory signals and the main effector mechanisms of the cell, thereby increasing the replication ability of both pathogens. However, little is known about the molecular events induced by HIV that causes reduced immune responsiveness of macrophages. Moreover, it is known that epigenetic alterations can regulate the transcription and expression of some key genes for the control or susceptibility to disease. Therefore, in this work, we aim to study whether HIV infection induces epigenetic changes and if those changes result in regulation of the immune response genes on macrophages, when these cells are infected in vitro by M. tuberculosis.

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Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
ESPINDOLA, MILENA S.; LIMA, LEONARDO J. G.; SOARES, LUANA S.; CACEMIRO, MAIRA C.; ZAMBUZI, FABIANA A.; GOMES, MATHEUS DE SOUZA; AMARAL, LAURENCE R.; BOLLELA, VALDES R.; MARTINS-FILHO, OLINDO A.; FRANTZ, FABIANI G.. Dysregulated Immune Activation in Second-Line HAART HIV plus Patients Is Similar to That of Untreated Patients. PLoS One, v. 10, n. 12, . (11/12512-0, 11/24026-3, 11/12199-0, 12/02799-3)
ESPINDOLA, MILENA S.; SOARES, LUANA S.; GALVAO-LIMA, LEONARDO J.; ZAMBUZI, FABIANA A.; CACEMIRO, MAIRA C.; BRAUER, VERONICA S.; MARZOCCHI-MACHADO, CLENI M.; GOMES, MATHEUS DE SOUZA; AMARAL, LAURENCE R.; MARTINS-FILHO, OLINDO A.; et al. Epigenetic alterations are associated with monocyte immune dysfunctions in HIV-1 infection. SCIENTIFIC REPORTS, v. 8, . (11/12512-0, 11/12199-0, 17/05365-8)
ESPINDOLA, MILENA S.; SOARES, LUANA S.; GALVAO-LIMA, LEONARDO J.; ZAMBUZI, FABIANA A.; CACEMIRO, MAIRA C.; BRAUER, VERNICA S.; FRANTZ, FABIANI G.. HIV infection: focus on the innate immune cells. IMMUNOLOGIC RESEARCH, v. 64, n. 5-6, p. 1118-1132, . (11/12512-0, 11/24026-3, 11/12199-0, 12/02799-3)

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