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Analysis of patterns of antibiotic sensitivity in pioneer strains of Streptococcus of the human oral cavity

Grant number: 11/09761-9
Support type:Scholarships in Brazil - Scientific Initiation
Effective date (Start): February 01, 2012
Effective date (End): December 31, 2013
Field of knowledge:Health Sciences - Dentistry
Principal researcher:Renata de Oliveira Mattos Graner
Grantee:Thaís Harder de Palma
Home Institution: Faculdade de Odontologia de Piracicaba (FOP). Universidade Estadual de Campinas (UNICAMP). Piracicaba , SP, Brazil
Associated scholarship(s):13/06820-0 - Analysis of the patterns of antibiotic sensitivity in pioneer strains of streptococci from the oral cavity, BE.EP.IC


The oral microbiota is characterized by a high amount and diversity of microorganisms, some of them may be pathogenic under specific environmental conditions. Non-hemolytic streptococcal species are predominant in most ecological niches of the mouth in adults and children. Several species of this genera are pioneer microorganisms in the mouth of young children and influence the development of oral microbiota through metabolic and genetic interactions with other microorganisms, and through interactions with host factors. The high microbial density of the oral ecological niches increases the genetic exchanges among organisms, promoting, for example, the spread of genes involved in antibiotic resistance. In two projects supported by FAPESP (proc. 2010/06785-1; 2010/06786-8), we are characterizing the major taxonomic groups of oral streptococci, which are pioneers of the oral cavity of babies, including species of the group's Mitis, Sanguinis, and Salivarius. The aim of this project is to characterize the sensitivity to different antibiotics in pioneer streptococcal isolates of the oral cavity of babies, which were classified into the major taxonomic groups of non-hemolytic streptococci. For that purpose, the minimum inhibitory concentration (MIC) of amoxicillin, erythromycin, tetracycline, doxycycline, streptomycin, and penicillin G will the determined in 279 strains, isolated from twenty-four children from 2 to 16 months of age, using the micro-dilution method. Minimum bactericidal concentration (MBC) will be also determined in a subset of strains of each taxonomic group identified as antibiotic-resistant based on the MIC data. The clinical strains of each taxonomic group will be compared with the respective reference strains regarding the profiles of antibiotic sensitivity.(AU)

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Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
PALMA, THAIS H.; HARTH-CHU, ERIKA N.; SCOTT, JODIE; STIPP, RAFAEL N.; BOISVERT, HEIKE; SALOMAO, MARIANA F.; THEOBALDO, JESSICA D.; POSSOBON, ROSANA F.; NASCIMENTO, LEANDRO C.; MCCAFFERTY, JONATHAN W.; et al. Oral cavities of healthy infants harbour high proportions of Streptococcus salivarius strains with phenotypic and genotypic resistance to multiple classes of antibiotics. Journal of Medical Microbiology, v. 65, n. 12, p. 1456-1464, . (13/06820-0, 11/09761-9, 09/50547-0, 10/06786-8, 12/51832-3, 10/06785-1, 15/12940-3)

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