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Evaluation of cellular immune response after treatment of squamous cell carcinoma in mice using photodynamic therapy

Grant number: 11/19752-7
Support Opportunities:Scholarships in Brazil - Scientific Initiation
Effective date (Start): December 01, 2011
Effective date (End): November 30, 2012
Field of knowledge:Biological Sciences - Morphology - Histology
Principal Investigator:José Roberto Machado Cunha da Silva
Grantee:Camila Lima Neves
Host Institution: Instituto de Ciências Biomédicas (ICB). Universidade de São Paulo (USP). São Paulo , SP, Brazil

Abstract

The squamous cell carcinoma (SCC) is one of the most common types of skin cancer non-melanoma in both animals and humans, it is caused mainly by ultraviolet radiation. The photodynamic therapy (PDT) is used clinically to treat a range of malignancies. This therapy uses photosensitizing molecules (PS) in the target tissue followed by irradiation with light, mainly in the red spectrum of visible light (>630 nm). The wavelength of the light source needs to be appropriate to generate reactive oxygen species (ROS) and/or singlet oxygen (1O2) that are able of causing the tumor death. One of the death mechanisms is the immune system activation. The main constituents of cellular immunity against cancer development are performed by the activation of T lymphocytes: helper (CD4+) and cytotoxic T (CD8+) as well as antigen-presenting cells (APCs) whose cells lead in the T cells activation, and in the skin this function is carried out by Langerhans cells. Moreover, cytokine secretions such as IL-1, TNF-alpha and IL-2 play an important role in the cancer development as well as in the immune response activation against cancer. The purpose of this research is to evaluate the mechanisms of action of PDT in an experimental model of SCC in vivo in the cellular immune response. (AU)

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Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
SILVA, ANA PAULA; NEVES, CAMILA LIMA; SILVA, ELIZANGELA DOS ANJOS; LIMA PORTELA, TANIA CRISTINA; IUNES, RENATA STECCA; COGLIATI, BRUNO; SEVERINO, DIVINOMAR; BAPTISTA, MAURICIO DA SILVA; ZAIDAN DAGLI, MARIA LUCIA; HERNANDEZ BLAZQUEZ, FRANCISCO JAVIER; et al. Effects of methylene blue-mediated photodynamic therapy on a mouse model of squamous cell carcinoma and normal skin. Photodiagnosis and Photodynamic Therapy, v. 23, p. 154-164, . (11/19752-7, 10/52675-3)

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