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Interactions of metal complexes with model membranes: Electron Paramagnetic Resonance and Differential Scannning Calorimetry Studies

Grant number: 11/15572-4
Support Opportunities:Scholarships in Brazil - Master
Effective date (Start): March 01, 2012
Effective date (End): February 28, 2013
Field of knowledge:Biological Sciences - Biophysics - Molecular Biophysics
Principal Investigator:Antonio José da Costa Filho
Grantee:Priscilla Freddi
Host Institution: Faculdade de Filosofia, Ciências e Letras de Ribeirão Preto (FFCLRP). Universidade de São Paulo (USP). Ribeirão Preto , SP, Brazil


Electron Paramagnetic Resonance (EPR) and spin labels are very importante tools for the study of the dynamic structure of biologically-relevant membranes. Changes in the organization of lipids induced by diverse agents, such as temperature and/or binding of low-molecular mass compounds, peptides, and proteins, can also be conveniently monitored by EPR. Furthermore, quantitative analysis can be achieved by the use of spectral simulations routines based on the Stochastic Liouville theory along with models for the lipid dynamics developed by Freed and co-workers. It has also proved interesting to add to EPR techniques a measure of a global quantity, such as the heat exchanged in thermal events, that give information about the processes mentioned above but now within a thermodynamic perspective. In the present project, we intend to use those methods to investigate the interaction between copper metal complexes, which have pharmacological interest, with lipid membranes. The project is a follow-up of a very productive collaboration between our group and Prof. Maria Torre's group (Universidad de La Republica, Uruguay), in which Prof. Torre has been synthesizing new metal transition compounds, in particular Cu(II), to use as pro-drugs. Hence, we will use metal complexes that have presented some pharmacological activity to study how those complexes go through the membrane of the cell they had activity against. This is a very basic issue that can certainly gain from detailed studies focused on a molecular description of the process.

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Academic Publications
(References retrieved automatically from State of São Paulo Research Institutions)
FREDDI, Priscilla. On the interactions between pharmacologically-relevant compounds and model membranes. 2013. Master's Dissertation - Universidade de São Paulo (USP). Faculdade de Filosofia, Ciências e Letras de Ribeirão Preto (PCARP/BC) Ribeirão Preto.

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