Osteoarthritis is one of the most prevalent causes of lameness in horses, and it is associated with poor performance, physical incapacity and early retirement of horses from sports. Articular cartilage is the key target of the degenerative disorders of osteoarthritis. Nowadays studies have attempted to overcome barriers of the articular cartilage repair. The bioengineering, used as a support in the standard therapies has contributed significantly not just for reduce the pain and joint deterioration, but even as an alternative therapy for regeneration. The Mesenchymal Stem Cells (MSC) has received a great importance in the treatment of osteoarthritis due to its therapeutic potential and a large immunomodulatory capacity. Similarly, the use of Platelet Rich Plasma (PRP) in animals with chondral defects has resulted in a significant decrease in pain and improvement in the rate of chondrocyte proliferation and extracellular matrix production. The use of microfractures as well supported therapy that has presented favorable results, applied in combination with the MSC and PRP, which is already known to be beneficial should still be investigated to enhance the articular cartilage repair. Therefore, the aim of this study will be to compare the effect of treatment only with microfractures to the microfractures associated with MSC and the PRP in articular cartilage defects experimentally induced by arthroscopy in the medial femoral trochlea of the patellofemoral joint of horses. This study attempts to an optimal approach to reducing the formation of fibrocartilage and reach the full recovery of the joint affected by osteoarthritis.
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