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Effect of exposure to titanium dioxide (TiO2)nanoparticles in curimbatá (Prochilodus lineatus, Teleostei): physiological, biochemical and morphological aspects

Grant number: 11/10339-0
Support Opportunities:Scholarships in Brazil - Doctorate
Effective date (Start): January 01, 2012
Effective date (End): November 30, 2014
Field of knowledge:Agronomical Sciences - Fishery Resources and Fishery Engineering - Inland Water Fishery Resources
Principal Investigator:Marisa Narciso Fernandes
Grantee:Talita Laurie Lustosa Do Carmo
Host Institution: Centro de Ciências Biológicas e da Saúde (CCBS). Universidade Federal de São Carlos (UFSCAR). São Carlos , SP, Brazil


The nanotechnology advancement, associated with the absence of specific regulations for the disposal of nanoparticles (NPs), increases the need to know the toxicity of NPs. Toxicological effects of titanium dioxide (TiO2) NPs are described for in vitro studies and in vivo studies in mammals, but there are few studies with aquatic organisms. Curimbatá, Prochilodus lineatus (Teleostei), is a potential bioindicator species and due to its detritivorous feeding habits, the fish are exposed to pollutants in water and in the sediment of aquatic systems. Due to its importance for subsistence and artisanal fishery, P. lineatus is consumed by human population and, if it is contaminated by NPs TiO2, may be toxic to consumers. Therefore, the species is an excellent model to investigate the environmental contamination. This way, project aims to evaluate the toxicity of TiO2 NPs determining the LC50- 48 h, as well as the effect of sublethal concentrations after acute (48 h) and chronic (14 d) exposure using biotransformation, antioxidants, ionic regulation, morphological and physiological biomarkers in P. lineatus. The sanity and sensitivity of animails will be tested using KCl as the reference substance and the LC50- 48 h of the TiO2 NPs to juvenile P. lineatus will be determined. After LC50- 48 h determination, the animals will be exposed to CL50/5, CL50/10, CL50/50, CL50/100 concentrations and a control group, in acute and chronic exposure to evaluate the effects and celullar responses using biotransformation, antioxidants, ionic regulation, morphological and physiological biomarkers. These assays will provide support for recognition of water bodies contamination by TiO2 NPs and about dietary risk with the consumption of fish exposed to TiO2 NPs.

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Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
CARMO, TALITA L. L.; SIQUEIRA, PRISCILA R.; AZEVEDO, VINICIUS C.; TAVARES, DRIELE; PESENTI, EMANUELE C.; CESTARI, MARTA M.; MARTINEZ, CLAUDIA B. R.; FERNANDES, MARISA N.. Overview of the toxic effects of titanium dioxide nanoparticles in blood, liver, muscles, and brain of a Neotropical detritivorous fish. ENVIRONMENTAL TOXICOLOGY, v. 34, n. 4, p. 457-468, . (14/05701-0, 11/10339-0)
CARMO, TALITA L. L.; AZEVEDO, VINICIUS C.; SIQUEIRA, PRISCILA R.; GALVAO, TIAGO D.; SANTOS, FABRICIO A.; MARTINEZ, CLAUDIA B. R.; APPOLONI, CARLOS R.; FERNANDES, MARISA N.. Mitochondria-rich cells adjustments and ionic balance in the Neotropical fish Prochilodus lineatus exposed to titanium dioxide nanoparticles. AQUATIC TOXICOLOGY, v. 200, p. 168-177, . (14/05701-0, 11/10339-0)

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