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Chemical and Biological studies of two Solanum species extracts presenting Moniliophthora perniciosa anti-fungi activity (cocoa witches´broom disease)

Grant number: 11/09349-0
Support Opportunities:Scholarships in Brazil - Scientific Initiation
Effective date (Start): December 01, 2011
Effective date (End): November 30, 2012
Field of knowledge:Agronomical Sciences - Agronomy
Principal Investigator:Simone Possedente de Lira
Grantee:Camila Furtunato da Silva
Host Institution: Escola Superior de Agricultura Luiz de Queiroz (ESALQ). Universidade de São Paulo (USP). Piracicaba , SP, Brazil


Brazil once was ahead of cocoa exportation therefore nowadays occupies the sixth position in the global market, with 160 thousand ton/year and 70 % of the cocoa farmland is located at south Bahia. The major fact to the production decreasing is due to the most aggressive cocoa disease, witches broom disease, caused by Moniliophthora perniciosa fungi, bringing severe damages to the plant and production.Early studies done by our research group proved the efficiency of leaf and fruit extracts isolated from Solanum lycopersicum with promising anti-fungi in vitro activity against M. perniciosa. At one hand, research of pharmacological use are intensively done, by other hand, agronomic interest on these kind of research are negligence by the scientific communityIn this project we propose to explore the biological and chemical potential from secondary metabolites produced by Solanum genera plants with anti-fungi activity to Moniliophthora perniciosa. After preliminary tests, two plants from Solanum genera will be selected, from each one leaves will be extracted using organic solvent generating crude extracts which will be analyzed. Crude extracts will be tested as its ability to inhibit M. perniciosa growth and pathogenicity. In Brazil, despite there are still few research groups working on secondary metabolites isolation of agronomic interest this work can be a new option for natural bio fungicides.

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Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
MARCIANO CORREA, JOZE APARECIDA; FORTKAMP, DIANA; DA SILVA, CAMILA FURTUNATO; ROCHA, FLAVIO; GOMES, LUIZ HUMBERTO; RONCATO DUARTE, KEILA MARIA; FERREIRA, ANTONIO GILBERTO; DE LIRA, SIMONE POSSEDENTE. Biological activity of 7 beta-acetoxywithanolide D isolated from Acnistus arborescens. SEMINA-CIENCIAS AGRARIAS, v. 39, n. 6, p. 2835-2841, . (12/02861-0, 13/50228-8, 14/15760-3, 11/09349-0)

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