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Statistical methods in evaluation of the efficacy of anthelmintic drugs in sheep naturally infected

Grant number: 11/12648-0
Support Opportunities:Scholarships in Brazil - Scientific Initiation
Effective date (Start): November 01, 2011
Effective date (End): October 31, 2012
Field of knowledge:Agronomical Sciences - Veterinary Medicine - Preventive Veterinary Medicine
Principal Investigator:Sílvia Helena Venturoli Perri
Grantee:Walter Bertequini Nagata
Host Institution: Faculdade de Medicina Veterinária (FMVA). Universidade Estadual Paulista (UNESP). Campus de Araçatuba. Araçatuba , SP, Brazil


Biostatistics is an important topic in biological field The conexion among different topics, as parasitology, provides interesting research and experimental data analysis helping researchers to find solutions specially to problem of this area The statistical tests, parametric and nonparametric support studies to evaluate and verify hypotheses. It´s very important to select appropriate statistical test to correct analysis of experiment. Statistical methods in the sheep industry could provide comparative analysis of medications effectiveness. Moreover, Brazilian sheep industry had growth and increased in importance recent years. The gastrointestinal nematode of small ruminants is the main health problem of this specie. The aim of this research is to evaluate the effectiveness of anti-helminthic currently available commercially using appropriate statistical tests depending on the nature of the data and assumptions of the tests in the evaluation of OPG. 350 animals will be selected from five commercial sheep farms with or without a history of anthelmintic resistance. From each farm, 70 animals will be divided into seven groups containing 10 animals each: Group 1 - control, Group 2 - Albendazole and Group 3 - levamisole hydrochloride, Group 4 - Ivermectin, Group 5 - Moxidectin and Group 6 - Closantel; Group 7 - Ivermectin + albendazole + levamisole. The results will be subjected to parametric or nonparametric tests, depending on the descriptive analysis. Statistical analysis will be performed with the computer programs SAS ® (Statitical Analysis System) and GraphPad InStat ®, and considered significant when P <0.05. (AU)

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Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
NAGATA, WALTER BERTEQUINI; DA CRUZ PANEGOSSI, MARIELE FERNANDA; SARAIVA BRESCIANI, KATIA DENISE; GOMES, JANCARLO FERREIRA; KANETO, CARLOS NORIUKI; VENTUROLI PERRI, SILVIA HELENA. Resistance of gastrointestinal nematodes to five different active principles in sheep infected naturally in Sao Paulo State, Brazil. Small Ruminant Research, v. 172, p. 48-50, . (11/12648-0)

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