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Evaluation of genotoxic and antigenotoxic potential of (-)-cubebin lignan in V79 cells by micronuclei assay

Grant number: 11/18219-3
Support Opportunities:Scholarships in Brazil - Scientific Initiation
Effective date (Start): January 01, 2012
Effective date (End): December 31, 2012
Field of knowledge:Biological Sciences - Genetics - Mutagenesis
Principal Investigator:Denise Crispim Tavares Barbosa
Grantee:Natália Helen Ferreira
Host Institution: Pró-Reitoria Adjunta de Pesquisa e Pós-Graduação. Universidade de Franca (UNIFRAN). Franca , SP, Brazil


The natural products are promising sources to discover new therapeutic potential agents. The substances of secondary metabolism are great economic interest and have being studied by researchers, since the plants are widely used in popular medicine. One of these substances is the lignans, belonging to one of the major classes of secondary metabolites, phenolic compounds. The (-)-cubebin is a compound isolated from the dried seeds of Piper cubeba. Both (-)-cubebin as its semi synthetic derivative (-)-hinokinin have activity against amastigotes of Trypanosoma cruzi. The (-)-cubebin has other biological activities, such as bacteriostatic, analgesic, anti-inflammatory, among others. It becomes relevant to assess the genotoxic potential of (-)-cubebin and its the influence on chromosomal damage induced by doxorubicin in Chinese hamster lung fibroblasts (V79 cells). In this sense, the frequency of micronuclei in 6000 binucleated cells/treatment will be used as a parameter of analysis. The nuclear division index, obtained from the analysis of 3000 cells/treatment, will be used to evaluate of cytotoxicity. These studies should contribute to a better understanding of action of (-)-cubebin in the human organism, in this way aiming at safer use of this compound. (AU)

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Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
ALVES DE REZENDE, ALEXANDRE AZENHA; MUNARI, CARLA CAROLINA; DE OLIVEIRA, POLLYANNA FRANCIELLI; FERREIRA, NATALIA HELEN; TAVARES, DENISE CRISPIM; ANDRADE E SILVA, MARCIO LUIS; SOUZA REZENDE, KAREN CRISTINA; SPANO, MARIO ANTONIO. A comparative study of the modulatory effects of (-)-cubebin on the mutagenicity/recombinogenicity induced by different chemical agents. Food and Chemical Toxicology, v. 55, p. 645-652, . (11/18219-3)

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