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Standardized extracts for the treatment of chronic diseases

Grant number: 11/08880-4
Support type:Scholarships in Brazil - Doctorate
Effective date (Start): November 01, 2011
Effective date (End): August 31, 2014
Field of knowledge:Health Sciences - Pharmacy - Pharmacognosy
Principal researcher:Wagner Vilegas
Grantee:Silvia Cristina Heredia Vieira
Home Institution: Faculdade de Ciências Farmacêuticas (FCFAR). Universidade Estadual Paulista (UNESP). Campus de Araraquara. Araraquara , SP, Brazil
Associated research grant:09/52237-9 - Standardized herbal medicines for the treatment of chronic diseases, AP.BTA.TEM


The aims of the project are to continue the integrated study chemical-pharmacological of Brazilian medicinal plants used in folk medicine and inserted in the Program Biota-FAPESP/CNPq - standardized herbal medicines for the treatment of chronic diseases; to establish the chemical profile, to isolate and to characterize the chemical constituents of the hydroalcoholic extract obtained from the leaves of Serjania marginata Casar. (Sapindaceae); to compare the chemical composition of the S. marginata native with the same cultivated species, collected in three periods of the growing cycle, to advance in the research to obtain of standardized herbal medicines and assess the acute toxicity and the antiulcer activity of the hydroalcoholic extract, enriched fractions and isolated substance(s). Pharmacognostic and chemical steps will performed in the Department of Chemistry at UNESP-Araraquara and will include the collection and processing of plant material, extraction, chromatographic screening, isolation and identification of substances, comparing the chemical composition of native plant with the cultivated and chemical standardization of extracts; the pharmacological step will be performed in the Department of Physiology at the Biosciences Institute of UNESP-Botucatu and will encompass the toxicity study and evaluation of antiulcer activity, using models of ethanol-induced gastric ulcers, the use of non-steroidal anti-inflammatory, by acetic acid and ligation of the pylorus, besides morphological and immunohistochemical analysis.

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Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
HEREDIA-VIEIRA, SILVIA C.; SIMONET, ANA M.; VILEGAS, WAGNER; MACIAS, FRANCISCO A.. Unusual C,O-Fused Glycosylapigenins from Serjania marginata Leaves. Journal of Natural Products, v. 78, n. 1, p. 77-84, . (09/52237-9, 11/08880-4)
Academic Publications
(References retrieved automatically from State of São Paulo Research Institutions)
VIEIRA, Silvia Cristina Heredia. Extratos padronizados para o tratamento de doenças crônicas: Serjania marginata Casar. (Sapindaceae). 2014. Doctoral Thesis - Universidade Estadual Paulista (Unesp). Faculdade de Ciências Farmacêuticas. Araraquara Araraquara.

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