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Effects of different vegetable oils in the maternal diet during pregnancy on the somatic and sensory-motor development in neonates rats

Grant number: 11/17574-4
Support Opportunities:Scholarships in Brazil - Scientific Initiation
Effective date (Start): October 01, 2011
Effective date (End): July 31, 2012
Field of knowledge:Health Sciences - Nutrition - Malnutrition and Physiological Development
Principal Investigator:Cristiano Mendes da Silva
Grantee:Tayane dos Santos Souto
Host Institution: Instituto de Saúde e Sociedade (ISS). Universidade Federal de São Paulo (UNIFESP). Campus Baixada Santista. Santos , SP, Brazil


Recent studies suggest that maternal diet during periods of pregnancy and/or lactation can cause changes morphofunctional on the nervous system of offspring, and is considered an important inducer of the "programming". In addition, maternal exposure to obesogenic diets (eg. high-fat diet) can permanently alter brain structure and function of the offspring. Therefore, the present study will investigate indicators of somatic and sensory-motor development in the offspring of rats female exposed to high-fat diets (with different sources of fatty acids) during pregnancy (1st to 21st days - pre-natal). Will be used newborn male Wistar rats divided into 4 groups, according to the maternal diet: 1. control diet, 2. high-fat diet with lard; 3. high-fat diet with soybean oil and 4. high-fat diet with canola oil. The indicators of development will be assessed during the lactation period (1st to 21st days postnatal) and were characterized as follows: 1) somatic development (body weight, body length, medio-lateral and and anteroposterior head axes) 2) maturation of physical characteristics (openings of the ear, ear canal, eyes, and eruption of incisors teeth) and 3) ontogeny of reflexes (palm grasp, righting, vibrissa placing, cliff avoidance, negative geotaxis, startle response and free fall righting). (AU)

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Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
SOUTO, TAYANE DOS SANTOS; NAGAMATSU NAKAO, FERNANDA SAYURI; GIRIKO, CATHERINE ASSUKA; DIAS, CLARISSA TAVARES; DO PRADO CHEBERLE, ANA ISABEL; LAMBERTUCCI, RAFAEL HERLING; MENDES-DA-SILVA, CRISTIANO. Lard-rich and canola oil-rich high-fat diets during pregnancy promote rats' offspring neurodevelopmental delay and behavioral disorders. Physiology & Behavior, v. 213, . (11/17577-3, 11/17574-4)
MENDES-DA-SILVA, CRISTIANO; GIRIKO, CATHERINE ASSUKA; MENNITTI, LAIS VALES; HOSOUME, LILIAN FAZION; SOUTO, TAYANE DOS SANTOS; DA SILVA, ALEXANDRE VALOTTA. Dieta materna rica em gordura durante a gravidez ou lactação altera o desenvolvimento somático e neurológico da prole. Arquivos de Neuro-Psiquiatria, v. 72, n. 2, p. 136-144, . (11/17577-3, 11/17574-4, 11/15329-2)
GIRIKO, CATHERINE ASSUKA; ANDREOLI, CARLA ALBUQUERQUE; MENNITTI, LAIS VALES; HOSOUME, LILIAN FAZION; SOUTO, TAYANE DOS SANTOS; DA SILVA, ALEXANDRE VALOTTA; MENDES-DA-SILVA, CRISTIANO. Delayed physical and neurobehavioral development and increased aggressive and depression-like behaviors in the rat offspring of dams fed a high-fat diet. INTERNATIONAL JOURNAL OF DEVELOPMENTAL NEUROSCIENCE, v. 31, n. 8, p. 731-739, . (11/17574-4, 11/15329-2)

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