Vasodilation effect induced by polimeric nanoparticle containing NO donor [Ru(bpy)2(py)NO2](PF6) (RuBPY)

Abstract

Nitric oxide (NO) is the main endogenous vasodilator that regulates vascular tone. There is a great interest in the development of compounds that may serve as vehicle to NO release in biological systems, mainly when the endogenous NO production is impaired, such as in hypertension.The nitrosyl ruthenium complexes have been widely studied as a new class of NO donors. These complexes are attractive as potential therapeutic agents due to its low toxicity. The release of NO from the complex cis-[Ru (bpy)2(py) NO2] (PF6) (RuBPY), chosen for this study is enzyme dependent. In addition, it has nitrite in its structure that releases NO inside the vascular smooth muscle cell. However, the NO donors are usually intravenously administered, which is an invasive route and has low acceptance by patients in therapy. The use of delivery systems has been widely studied to protect the drug and to increase its bioavailability. These delivery systems allow the oral administration of drugs on their own would not be administered by this route due to the low absorption generated by the presence of enzymes and different pH at which these drugs are exposed. Thus, the objective of this project is to encapsulate the complex RuBPY in a polymeric nanoparticle and to study the vasodilator effect in vitro and in vivo of this delivery system administered by oral route. (AU)