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Genotoxic and epigenetic changes in DNA of mice exposed to particulate matter (PM 2,5)

Grant number: 11/09891-0
Support Opportunities:Scholarships in Brazil - Scientific Initiation
Effective date (Start): September 01, 2011
Effective date (End): June 30, 2012
Field of knowledge:Health Sciences - Pharmacy - Toxicological Analysis
Principal Investigator:Ana Paula de Melo Loureiro
Grantee:Antonio Anáx Falcão de Oliveira
Host Institution: Faculdade de Ciências Farmacêuticas (FCF). Universidade de São Paulo (USP). São Paulo , SP, Brazil


Exposure to air pollution constituents can damage biomolecules, leading to diseases such as cancer. Fine particles with an aerodynamic diameter of fewer than 2.5 micrometers (MP2,5) draw attention because they can penetrate the respiratory tract and be deposited in the terminal portion of the bronchi and alveoli, causing cell damage. Such particles have variable compositions and may act as carriers of polycyclic aromatic hydrocarbons (PAHs) such as benzo[a]pyrene, metal, and water-soluble ions. Given the capacity of its constituents to cause damage to the DNA, it is evident the probable relationship of the particulate matter with the appearance of pathologies linked to the respiratory tract and probably other body tissues. This justifies the importance of further studies in order to deepen the knowledge about the health risks caused by this type of pollutant, primarily in other organs such as the liver and kidney that are directly linked to the metabolism and excretion of xenobiotics. Therefore, this project proposes the evaluation of global DNA methylation and DNA damage caused by oxidative stress and inflammation in lung, liver, and kidney of Swiss and A/J mice chronically exposed to particulate matter concentrated from the air of the city of Sao Paulo, Cerqueira Cesar region in the Faculty of Medicine, University of São Paulo. (AU).

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Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
FALCAO DE OLIVEIRA, ANTONIO ANAX; DE OLIVEIRA, TIAGO FRANCO; DIAS, MICHELLE FRANCINI; GENNARI MEDEIROS, MARISA HELENA; DI MASCIO, PAOLO; VERAS, MARIANA; LEMOS, MIRIAM; MARCOURAKIS, TANIA; NASCIMENTO SALDIVA, PAULO HILARIO; MELO LOUREIRO, ANA PAULA. Genotoxic and epigenotoxic effects in mice exposed to concentrated ambient fine particulate matter (PM2.5) from SAo Paulo city, Brazil. PARTICLE AND FIBRE TOXICOLOGY, v. 15, . (12/08617-4, 12/08616-8, 11/09891-0, 12/22190-3, 12/21636-8, 13/07937-8)
DE OLIVEIRA, TIAGO FRANCO; FELCAO DE OLIVEIRA, ANTONIO ANAX; LEMOS, MIRIAM; VERAS, MARIANA; NASCIMENTO SALDIVA, PAULO HILARIO; GENNARI DE MEDEIROS, MARISA HELENA; DI MASCIO, PAOLO; DE MELO LOUREIRO, ANA PAULA. Quantification of three DNA Lesions by Mass Spectrometry and Assessment of Their Levels in Tissues of Mice Exposed to Ambient Fine Particulate Matter. JOVE-JOURNAL OF VISUALIZED EXPERIMENTS, n. 147, . (13/07937-8, 11/09891-0, 12/08617-4, 12/21636-8, 12/08616-8, 12/22190-3)

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