Exposure to air pollution constituents can damage biomolecules, leading to diseases such as cancer. Fine particles with an aerodynamic diameter of fewer than 2.5 micrometers (MP2,5) draw attention because they can penetrate the respiratory tract and be deposited in the terminal portion of the bronchi and alveoli, causing cell damage. Such particles have variable compositions and may act as carriers of polycyclic aromatic hydrocarbons (PAHs) such as benzo[a]pyrene, metal, and water-soluble ions. Given the capacity of its constituents to cause damage to the DNA, it is evident the probable relationship of the particulate matter with the appearance of pathologies linked to the respiratory tract and probably other body tissues. This justifies the importance of further studies in order to deepen the knowledge about the health risks caused by this type of pollutant, primarily in other organs such as the liver and kidney that are directly linked to the metabolism and excretion of xenobiotics. Therefore, this project proposes the evaluation of global DNA methylation and DNA damage caused by oxidative stress and inflammation in lung, liver, and kidney of Swiss and A/J mice chronically exposed to particulate matter concentrated from the air of the city of Sao Paulo, Cerqueira Cesar region in the Faculty of Medicine, University of São Paulo. (AU).
News published in Agência FAPESP Newsletter about the scholarship: